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Literature DB >> 20502506

Modulation of the activity of dopaminergic neurons by SK channels: a potential target for the treatment of Parkinson's disease?

Xiao-Kun Liu¹, Gang Wang, Sheng-Di Chen.

Abstract

SK channels are small conductance calcium-activated potassium channels that are widely expressed in different neurons with distinct subtypes. They play an important role in modulating synaptic plasticity, dopaminergic neurotransmission, and learning and memory. The present review was mainly focused on the recent findings on the contradictory roles of SK channels in modulating dopaminergic neurons in substantia nigra and in the pathogenesis of Parkinson's disease (PD). Besides, whether modulation of SK channels could be a potential target for PD treatment was also discussed.

Entities: Disease

Mesh：

Substances：

Year: 2010 PMID： 20502506 PMCID： PMC5560298 DOI： 10.1007/s12264-010-1217-4

Source DB: PubMed Journal: Neurosci Bull ISSN： 1995-8218 Impact factor: 5.203

33 in total

Review 1. Small-conductance calcium-activated potassium channels.

Authors: C T Bond; J Maylie; J P Adelman
Journal: Ann N Y Acad Sci Date: 1999-04-30 Impact factor: 5.691

2. Distribution of the messenger RNA for the small conductance calcium-activated potassium channel SK3 in the adult rat brain and correlation with immunoreactivity.

Authors: S Tacconi; R Carletti; B Bunnemann; C Plumpton; E Merlo Pich; G C Terstappen
Journal: Neuroscience Date: 2001 Impact factor: 3.590

Review 3. Channels underlying neuronal calcium-activated potassium currents.

Authors: Pankaj Sah; E S Louise Faber
Journal: Prog Neurobiol Date: 2002-04 Impact factor: 11.685

4. Apamin-induced irregular firing in vitro and irregular single-spike firing observed in vivo in dopamine neurons is chaotic.

Authors: L P Lovejoy; P D Shepard; C C Canavier
Journal: Neuroscience Date: 2001 Impact factor: 3.590

Review 5. SK channels in excitability, pacemaking and synaptic integration.

Authors: Chris T Bond; James Maylie; John P Adelman
Journal: Curr Opin Neurobiol Date: 2005-06 Impact factor: 6.627

Review 6. ATP-sensitive potassium channels: novel potential roles in Parkinson's disease.

Authors: Jie Zeng; Gang Wang; Sheng-Di Chen
Journal: Neurosci Bull Date: 2007-11 Impact factor: 5.203

Review 7. Functions of SK channels in central neurons.

Authors: E S Louise Faber; Pankaj Sah
Journal: Clin Exp Pharmacol Physiol Date: 2007-10 Impact factor: 2.557

Review 8. Modulation of small conductance calcium-activated potassium (SK) channels: a new challenge in medicinal chemistry.

Authors: J-F Liégeois; F Mercier; A Graulich; F Graulich-Lorge; J Scuvée-Moreau; V Seutin
Journal: Curr Med Chem Date: 2003-04 Impact factor: 4.530

9. Inhibition of brain mitochondrial respiration by dopamine: involvement of H(2)O(2) and hydroxyl radicals but not glutathione-protein-mixed disulfides.

Authors: Martin Gluck; Julie Ehrhart; Elizabeth Jayatilleke; Gail D Zeevalk
Journal: J Neurochem Date: 2002-07 Impact factor: 5.372

Review 10. Small conductance Ca2+-activated K+ channels as targets of CNS drug development.

Authors: Thomas Blank; Ingrid Nijholt; Min-Jeong Kye; Joachim Spiess
Journal: Curr Drug Targets CNS Neurol Disord Date: 2004-06

7 in total

1. Subtype-selective positive modulation of K_Ca 2 channels depends on the HA/HB helices.

Authors: Young-Woo Nam; Meng Cui; Naglaa Salem El-Sayed; Razan Orfali; Misa Nguyen; Grace Yang; Mohammad Asikur Rahman; Judy Lee; Miao Zhang
Journal: Br J Pharmacol Date: 2021-10-01 Impact factor: 8.739

Review 2. Altered neural cell junctions and ion-channels leading to disrupted neuron communication in Parkinson's disease.

Authors: Saptamita Paul Choudhury; Sarika Bano; Srijon Sen; Kapil Suchal; Saroj Kumar; Fredrik Nikolajeff; Sanjay Kumar Dey; Vaibhav Sharma
Journal: NPJ Parkinsons Dis Date: 2022-06-01

Review 3. Potassium Channels: A Potential Therapeutic Target for Parkinson's Disease.

Authors: Xiaoyan Chen; Bao Xue; Jun Wang; Haixia Liu; Limin Shi; Junxia Xie
Journal: Neurosci Bull Date: 2017-09-07 Impact factor: 5.203

Review 4. Targeting the Small- and Intermediate-Conductance Ca-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin Interface.

Authors: Meng Cui; Guangrong Qin; Kunqian Yu; M Scott Bowers; Miao Zhang
Journal: Neurosignals Date: 2014-10-08

Modulation of the activity of dopaminergic neurons by SK channels: a potential target for the treatment of Parkinson's disease?

Review 1. Small-conductance calcium-activated potassium channels.

2. Distribution of the messenger RNA for the small conductance calcium-activated potassium channel SK3 in the adult rat brain and correlation with immunoreactivity.

Review 3. Channels underlying neuronal calcium-activated potassium currents.

4. Apamin-induced irregular firing in vitro and irregular single-spike firing observed in vivo in dopamine neurons is chaotic.

Review 5. SK channels in excitability, pacemaking and synaptic integration.

Review 6. ATP-sensitive potassium channels: novel potential roles in Parkinson's disease.

Review 7. Functions of SK channels in central neurons.

Review 8. Modulation of small conductance calcium-activated potassium (SK) channels: a new challenge in medicinal chemistry.

9. Inhibition of brain mitochondrial respiration by dopamine: involvement of H(2)O(2) and hydroxyl radicals but not glutathione-protein-mixed disulfides.

Review 10. Small conductance Ca2+-activated K+ channels as targets of CNS drug development.

1. Subtype-selective positive modulation of K_Ca 2 channels depends on the HA/HB helices.

Review 2. Altered neural cell junctions and ion-channels leading to disrupted neuron communication in Parkinson's disease.

Review 3. Potassium Channels: A Potential Therapeutic Target for Parkinson's Disease.

Review 4. Targeting the Small- and Intermediate-Conductance Ca-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin Interface.

Review 5. Conotoxins that confer therapeutic possibilities.

6. Hydrophobic interactions between the HA helix and S4-S5 linker modulate apparent Ca²⁺ sensitivity of SK2 channels.

7. SK3 Channel Overexpression in Mice Causes Hippocampal Shrinkage Associated with Cognitive Impairments.

Modulation of the activity of dopaminergic neurons by SK channels: a potential target for the treatment of Parkinson's disease?

Review 1. Small-conductance calcium-activated potassium channels.

2. Distribution of the messenger RNA for the small conductance calcium-activated potassium channel SK3 in the adult rat brain and correlation with immunoreactivity.

Review 3. Channels underlying neuronal calcium-activated potassium currents.

4. Apamin-induced irregular firing in vitro and irregular single-spike firing observed in vivo in dopamine neurons is chaotic.

Review 5. SK channels in excitability, pacemaking and synaptic integration.

Review 6. ATP-sensitive potassium channels: novel potential roles in Parkinson's disease.

Review 7. Functions of SK channels in central neurons.

Review 8. Modulation of small conductance calcium-activated potassium (SK) channels: a new challenge in medicinal chemistry.

9. Inhibition of brain mitochondrial respiration by dopamine: involvement of H(2)O(2) and hydroxyl radicals but not glutathione-protein-mixed disulfides.

Review 10. Small conductance Ca2+-activated K+ channels as targets of CNS drug development.

1. Subtype-selective positive modulation of KCa 2 channels depends on the HA/HB helices.

Review 2. Altered neural cell junctions and ion-channels leading to disrupted neuron communication in Parkinson's disease.

Review 3. Potassium Channels: A Potential Therapeutic Target for Parkinson's Disease.

Review 4. Targeting the Small- and Intermediate-Conductance Ca-Activated Potassium Channels: The Drug-Binding Pocket at the Channel/Calmodulin Interface.

Review 5. Conotoxins that confer therapeutic possibilities.

6. Hydrophobic interactions between the HA helix and S4-S5 linker modulate apparent Ca2+ sensitivity of SK2 channels.

7. SK3 Channel Overexpression in Mice Causes Hippocampal Shrinkage Associated with Cognitive Impairments.

1. Subtype-selective positive modulation of K_Ca 2 channels depends on the HA/HB helices.

6. Hydrophobic interactions between the HA helix and S4-S5 linker modulate apparent Ca²⁺ sensitivity of SK2 channels.