BACKGROUND: Higher serum uric acid (SUA) levels have been shown to be associated with cardiovascular disease. SUA levels are also associated with hypertension, a strong risk factor for chronic kidney disease (CKD). However, it is unclear whether SUA is independently associated with CKD. We examined the hypothesis that higher SUA levels are positively associated with CKD. METHODS: We analysed data from the C8 Health Study, a population-based study of Appalachian adults aged ≥18 years and free of cardiovascular disease (n = 49,295, 53% women). SUA was examined as gender-specific quartiles. The outcome of interest was CKD (n = 2,980), defined as an estimated glomerular filtration rate of <60 mL/min/1.73 m(2) from serum creatinine. RESULTS: Overall, we observed a clear positive association between increasing quartiles of SUA and CKD, independent of confounders. Compared with the lowest quartile of SUA (referent), the multivariable odds ratios (95% confidence interval) for quartiles 2-4, respectively, of CKD were 1.53 (1.31, 1.78), 2.16 (1.86 2.50) and 4.67 (4.07, 5.36); P-trend < 0.0001. This observed positive association persisted in separate analysis among men (P-trend < 0.0001) and women (P-trend < 0.0001). CONCLUSIONS: In conclusion, higher SUA levels are positively associated with CKD, suggesting that at least part of the reported association between SUA and cardiovascular disease may be mediated by CKD.
BACKGROUND: Higher serum uric acid (SUA) levels have been shown to be associated with cardiovascular disease. SUA levels are also associated with hypertension, a strong risk factor for chronic kidney disease (CKD). However, it is unclear whether SUA is independently associated with CKD. We examined the hypothesis that higher SUA levels are positively associated with CKD. METHODS: We analysed data from the C8 Health Study, a population-based study of Appalachian adults aged ≥18 years and free of cardiovascular disease (n = 49,295, 53% women). SUA was examined as gender-specific quartiles. The outcome of interest was CKD (n = 2,980), defined as an estimated glomerular filtration rate of <60 mL/min/1.73 m(2) from serum creatinine. RESULTS: Overall, we observed a clear positive association between increasing quartiles of SUA and CKD, independent of confounders. Compared with the lowest quartile of SUA (referent), the multivariable odds ratios (95% confidence interval) for quartiles 2-4, respectively, of CKD were 1.53 (1.31, 1.78), 2.16 (1.86 2.50) and 4.67 (4.07, 5.36); P-trend < 0.0001. This observed positive association persisted in separate analysis among men (P-trend < 0.0001) and women (P-trend < 0.0001). CONCLUSIONS: In conclusion, higher SUA levels are positively associated with CKD, suggesting that at least part of the reported association between SUA and cardiovascular disease may be mediated by CKD.
Authors: Abbas Dehghan; Mandy van Hoek; Eric J G Sijbrands; Albert Hofman; Jacqueline C M Witteman Journal: Diabetes Care Date: 2007-10-31 Impact factor: 19.112
Authors: Andrew S Levey; Josef Coresh; Tom Greene; Lesley A Stevens; Yaping Lucy Zhang; Stephen Hendriksen; John W Kusek; Frederick Van Lente Journal: Ann Intern Med Date: 2006-08-15 Impact factor: 25.391
Authors: Satish A Eraly; Volker Vallon; Timo Rieg; Jon A Gangoiti; William R Wikoff; Gary Siuzdak; Bruce A Barshop; Sanjay K Nigam Journal: Physiol Genomics Date: 2008-02-12 Impact factor: 3.107
Authors: S Bo; R Gambino; M Durazzo; F Ghione; G Musso; L Gentile; M Cassader; P Cavallo-Perin; G Pagano Journal: J Endocrinol Invest Date: 2008-06 Impact factor: 4.256
Authors: Michel Chonchol; Michael G Shlipak; Ronit Katz; Mark J Sarnak; Anne B Newman; David S Siscovick; Bryan Kestenbaum; Jan Kirk Carney; Linda F Fried Journal: Am J Kidney Dis Date: 2007-08 Impact factor: 8.860
Authors: Magdalena Madero; Mark J Sarnak; Xuelei Wang; Tom Greene; Gerald J Beck; John W Kusek; Allan J Collins; Andrew S Levey; Vandana Menon Journal: Am J Kidney Dis Date: 2009-03-20 Impact factor: 8.860
Authors: Stacey E Jolly; Mihriye Mete; Hong Wang; Jianhui Zhu; Sven O E Ebbesson; V Saroja Voruganti; Anthony G Comuzzie; Barbara V Howard; Jason G Umans Journal: J Clin Hypertens (Greenwich) Date: 2012-01-04 Impact factor: 3.738
Authors: Nicolas Macías; Marian Goicoechea; M S García de Vinuesa; Ursula Verdalles; Jose Luño Journal: Curr Rheumatol Rep Date: 2013-12 Impact factor: 4.592