BACKGROUND AND PURPOSE: To assess the predictive value of T2 lesions on the rate of progression of disability in multiple sclerosis (MS). METHODS: We reanalyzed T2 lesion number and load on brain MRI scans, performed before 1997, of 186 MS patients, who were clinically followed. There were 90 patients with progressive MS (35 secondary progressive and 55 primary progressive), and 96 with relapsing remitting MS. The rate of progression of disability was measured by time to sustained progression of disability (defined as an increase in ≥ 1 point when the Expanded Disability Status Scale (EDSS) was 5.5 or less and an increase in EDSS of ≥ 0.5 point when the EDSS was 6.0 or higher), and by the Multiple Sclerosis Severity Score (MSSS). RESULTS: During follow-up (median 15 years, IQR 12-17 years), 94% of the patients with progressive MS and 50% of the patients with relapsing remitting MS had progression of disability. Higher T2 lesion number and load were modestly associated with a higher rate of disease progression on the MSSS and a shorter time to progression of disability in relapsing remitting MS, but not in progressive MS. CONCLUSIONS: Our findings indicate that the amount of T2 lesions has a small predictive value for progression of disability in relapsing remitting MS, but has no influence on the rate of progression in progressive MS.
BACKGROUND AND PURPOSE: To assess the predictive value of T2 lesions on the rate of progression of disability in multiple sclerosis (MS). METHODS: We reanalyzed T2 lesion number and load on brain MRI scans, performed before 1997, of 186 MS patients, who were clinically followed. There were 90 patients with progressive MS (35 secondary progressive and 55 primary progressive), and 96 with relapsing remitting MS. The rate of progression of disability was measured by time to sustained progression of disability (defined as an increase in ≥ 1 point when the Expanded Disability Status Scale (EDSS) was 5.5 or less and an increase in EDSS of ≥ 0.5 point when the EDSS was 6.0 or higher), and by the Multiple Sclerosis Severity Score (MSSS). RESULTS: During follow-up (median 15 years, IQR 12-17 years), 94% of the patients with progressive MS and 50% of the patients with relapsing remitting MS had progression of disability. Higher T2 lesion number and load were modestly associated with a higher rate of disease progression on the MSSS and a shorter time to progression of disability in relapsing remitting MS, but not in progressive MS. CONCLUSIONS: Our findings indicate that the amount of T2 lesions has a small predictive value for progression of disability in relapsing remitting MS, but has no influence on the rate of progression in progressive MS.
Authors: Giancarlo Comi; Stuart D Cook; Gavin Giovannoni; Kottil Rammohan; Peter Rieckmann; Per Soelberg Sørensen; Patrick Vermersch; Anthony C Hamlett; Vissia Viglietta; Steven J Greenberg Journal: J Neurol Date: 2012-12-21 Impact factor: 4.849
Authors: Nermin Serbecic; Fahmy Aboul-Enein; Sven C Beutelspacher; Clemens Vass; Wolfgang Kristoferitsch; Hans Lassmann; Andreas Reitner; Ursula Schmidt-Erfurth Journal: PLoS One Date: 2011-05-17 Impact factor: 3.240
Authors: Laura E Jonkman; Alexandra Lopez Soriano; Sandra Amor; Frederik Barkhof; Paul van der Valk; Hugo Vrenken; Jeroen J G Geurts Journal: J Neurol Date: 2015-03-13 Impact factor: 4.849
Authors: Peter Connick; Floriana De Angelis; Richard A Parker; Domenico Plantone; Anisha Doshi; Nevin John; Jonathan Stutters; David MacManus; Ferran Prados Carrasco; Frederik Barkhof; Sebastien Ourselin; Marie Braisher; Moira Ross; Gina Cranswick; Sue H Pavitt; Gavin Giovannoni; Claudia Angela Gandini Wheeler-Kingshott; Clive Hawkins; Basil Sharrack; Roger Bastow; Christopher J Weir; Nigel Stallard; Siddharthan Chandran; Jeremy Chataway Journal: BMJ Open Date: 2018-08-30 Impact factor: 2.692