OBJECTIVE: To determine whether non-surgical periodontal treatment (PT) would exert, in subjects with generalized chronic periodontitis (GCP), some beneficial effect on renal function as indicated by surrogate measures of the glomerular filtration rate (GFR). MATERIAL AND METHODS: Twenty GCP systemically healthy subjects were treated with PT. Serum samples were collected at baseline and 1 day, 7, 30, 90 and 180 days after treatment. GFR was evaluated using cystatin C, a serum marker and modification of diet in renal disease (MDRD), an equation involving creatinine, urea and albumin. Serum markers of systemic inflammation such as C-reactive protein (CRP), D-dimer, serum amyloid A (SAA) and fibrinogen were also assessed. RESULTS: The cystatin C level decreased significantly from baseline to the end of the trial (p<0.01). Conversely, MDRD did not vary. A significant inflammatory reaction was produced by PT in the short term. Greater increases were noted for CRP and SAA within 24 h (p<0.001 versus baseline), while D-dimer (p<0.05) and fibrinogen (p<0.01) showed mild variations. The values of inflammatory markers were normalized after 30 days. CONCLUSIONS: GFR, as assessed by cystatin C levels, may be positively affected by PT. Because of the exploratory nature of this trial, further research is needed to investigate this preliminary finding.
OBJECTIVE: To determine whether non-surgical periodontal treatment (PT) would exert, in subjects with generalized chronic periodontitis (GCP), some beneficial effect on renal function as indicated by surrogate measures of the glomerular filtration rate (GFR). MATERIAL AND METHODS: Twenty GCP systemically healthy subjects were treated with PT. Serum samples were collected at baseline and 1 day, 7, 30, 90 and 180 days after treatment. GFR was evaluated using cystatin C, a serum marker and modification of diet in renal disease (MDRD), an equation involving creatinine, urea and albumin. Serum markers of systemic inflammation such as C-reactive protein (CRP), D-dimer, serum amyloid A (SAA) and fibrinogen were also assessed. RESULTS: The cystatin C level decreased significantly from baseline to the end of the trial (p<0.01). Conversely, MDRD did not vary. A significant inflammatory reaction was produced by PT in the short term. Greater increases were noted for CRP and SAA within 24 h (p<0.001 versus baseline), while D-dimer (p<0.05) and fibrinogen (p<0.01) showed mild variations. The values of inflammatory markers were normalized after 30 days. CONCLUSIONS: GFR, as assessed by cystatin C levels, may be positively affected by PT. Because of the exploratory nature of this trial, further research is needed to investigate this preliminary finding.
Authors: Vanessa Grubbs; Faviola Garcia; Bonnie L Jue; Eric Vittinghoff; Mark Ryder; David Lovett; Jacqueline Carrillo; Steven Offenbacher; Peter Ganz; Kirsten Bibbins-Domingo; Neil R Powe Journal: Contemp Clin Trials Date: 2016-12-20 Impact factor: 2.226
Authors: Dan Zhao; Abrar Tahir Khawaja; Lijian Jin; Kam Wa Chan; Maurizio Tonetti; Sydney Chi Wai Tang; George Pelekos Journal: Clin Oral Investig Date: 2019-11-12 Impact factor: 3.573
Authors: Lisa Jamieson; Michael Skilton; Louise Maple-Brown; Kostas Kapellas; Lisa Askie; Jaqui Hughes; Peter Arrow; Sajiv Cherian; David Fernandes; Basant Pawar; Alex Brown; John Boffa; Wendy Hoy; David Harris; Nicole Mueller; Alan Cass Journal: BMC Nephrol Date: 2015-10-31 Impact factor: 2.388