Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae.

Literature DB >> 20498319

Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae.

Dorothea Zähner¹, Xiaoliu Zhou, Scott T Chancey, Jan Pohl, William M Shafer, David S Stephens.

Abstract

Macrolide resistance is a major concern in the treatment of Streptococcus pneumoniae. Inducible macrolide resistance in this pneumococcus is mediated by the efflux pump MefE/Mel. We show here that the human antimicrobial peptide LL-37 induces the mefE promoter and confers resistance to erythromycin and LL-37. Such induction may impact the efficacy of host defenses and of macrolide-based treatment of pneumococcal disease.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2010 PMID： 20498319 PMCID： PMC2916318 DOI： 10.1128/AAC.01756-09

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

37 in total

1. In vivo veritas: in vitro macrolide resistance in systemic Streptococcus pneumoniae infections does result in clinical failure.

Authors: Michael R Jacobs
Journal: Clin Infect Dis Date: 2002-08-09 Impact factor: 9.079

2. Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family.

Authors: W M Shafer; X Qu; A J Waring; R I Lehrer
Journal: Proc Natl Acad Sci U S A Date: 1998-02-17 Impact factor: 11.205

3. Capsule and D-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps.

Authors: Florian Wartha; Katharina Beiter; Barbara Albiger; Jenny Fernebro; Arturo Zychlinsky; Staffan Normark; Birgitta Henriques-Normark
Journal: Cell Microbiol Date: 2007-01-09 Impact factor: 3.715

4. The pgdA gene encodes for a peptidoglycan N-acetylglucosamine deacetylase in Streptococcus pneumoniae.

Authors: W Vollmer; A Tomasz
Journal: J Biol Chem Date: 2000-07-07 Impact factor: 5.157

5. Endogenous antimicrobial peptides and skin infections in atopic dermatitis.

Authors: Peck Y Ong; Takaaki Ohtake; Corinne Brandt; Ian Strickland; Mark Boguniewicz; Tomas Ganz; Richard L Gallo; Donald Y M Leung
Journal: N Engl J Med Date: 2002-10-10 Impact factor: 91.245

6. Breakthrough pneumococcal bacteremia in patients being treated with azithromycin and clarithromycin.

Authors: M A Kelley; D J Weber; P Gilligan; M S Cohen
Journal: Clin Infect Dis Date: 2000-10-13 Impact factor: 9.079

7. Role of putative virulence factors of Streptococcus pyogenes in mouse models of long-term throat colonization and pneumonia.

Authors: L K Husmann; D L Yung; S K Hollingshead; J R Scott
Journal: Infect Immun Date: 1997-04 Impact factor: 3.441

8. Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system.

Authors: J Sutcliffe; A Tait-Kamradt; L Wondrack
Journal: Antimicrob Agents Chemother Date: 1996-08 Impact factor: 5.191

9. Generic and specific adaptive responses of Streptococcus pneumoniae to challenge with three distinct antimicrobial peptides, bacitracin, LL-37, and nisin.

Authors: Joanna A Majchrzykiewicz; Oscar P Kuipers; Jetta J E Bijlsma
Journal: Antimicrob Agents Chemother Date: 2009-11-16 Impact factor: 5.191

Review 10. Hidden epidemic of macrolide-resistant pneumococci.

Authors: Keith P Klugman; John R Lonks
Journal: Emerg Infect Dis Date: 2005-06 Impact factor: 6.883

26 in total

1. The cysteine protease ApdS from Streptococcus suis promotes evasion of innate immune defenses by cleaving the antimicrobial peptide cathelicidin LL-37.

Authors: Fang Xie; Yanan Zan; Yueling Zhang; Ning Zheng; Qiulong Yan; Wanjiang Zhang; Huihui Zhang; Mingjie Jin; Fuguang Chen; Xinyuan Zhang; Siguo Liu
Journal: J Biol Chem Date: 2019-10-16 Impact factor: 5.157

Human antimicrobial peptide LL-37 induces MefE/Mel-mediated macrolide resistance in Streptococcus pneumoniae.

1. In vivo veritas: in vitro macrolide resistance in systemic Streptococcus pneumoniae infections does result in clinical failure.

2. Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family.

3. Capsule and D-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps.

4. The pgdA gene encodes for a peptidoglycan N-acetylglucosamine deacetylase in Streptococcus pneumoniae.

5. Endogenous antimicrobial peptides and skin infections in atopic dermatitis.

6. Breakthrough pneumococcal bacteremia in patients being treated with azithromycin and clarithromycin.

7. Role of putative virulence factors of Streptococcus pyogenes in mouse models of long-term throat colonization and pneumonia.

8. Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern mediated by an efflux system.

9. Generic and specific adaptive responses of Streptococcus pneumoniae to challenge with three distinct antimicrobial peptides, bacitracin, LL-37, and nisin.

Review 10. Hidden epidemic of macrolide-resistant pneumococci.

1. The cysteine protease ApdS from Streptococcus suis promotes evasion of innate immune defenses by cleaving the antimicrobial peptide cathelicidin LL-37.

Review 2. Bacterial strategies of resistance to antimicrobial peptides.

Review 3. Adaptive and mutational resistance: role of porins and efflux pumps in drug resistance.

4. Acceleration of tuberculosis treatment by adjunctive therapy with verapamil as an efflux inhibitor.

5. Drug tolerance in replicating mycobacteria mediated by a macrophage-induced efflux mechanism.

6. Induction of efflux-mediated macrolide resistance in Streptococcus pneumoniae.

Review 7. Resistance to Macrolide Antibiotics in Public Health Pathogens.

8. Antimicrobial efflux pumps and Mycobacterium tuberculosis drug tolerance: evolutionary considerations.

Review 9. Acquired inducible antimicrobial resistance in Gram-positive bacteria.

Review 10. Bacterial Evasion of Host Antimicrobial Peptide Defenses.