Literature DB >> 20498313

Mutant selection window and characterization of allelic diversity for ciprofloxacin-resistant mutants of Rhodococcus equi.

Hidekazu Niwa1, Brent A Lasker.   

Abstract

The mutant prevention concentration (MPC) for ciprofloxacin was determined for two Rhodococcus equi strains. The MPC for both strains was 32 mug/ml, which is above the peak serum concentration of ciprofloxacin obtainable by oral administration in humans. Nine single nucleotide changes corresponding to eight amino acid substitutions in the quinolone resistance-determining regions of DNA gyrase subunits A and B were characterized. Only mutants with amino acid changes in Ser-83 of GyrA were highly resistant (>or=64 microg/ml). Our results suggest that ciprofloxacin monotherapy against R. equi infection may result in the emergence of ciprofloxacin-resistant mutants.

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Year:  2010        PMID： 20498313      PMCID： PMC2916315          DOI： 10.1128/AAC.01670-09

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  25 in total

1.  Rhodococcus equi nosocomial meningitis cured by levofloxacin and shunt removal.

Authors:  P G Scotton; E Tonon; M Giobbia; M Gallucci; R Rigoli; A Vaglia
Journal:  Clin Infect Dis       Date:  2000-01       Impact factor: 9.079

2.  Susceptibility to levofloxacin of Myocobacterium tuberculosis isolates from patients with HIV-related tuberculosis and characterization of a strain with levofloxacin monoresistance. Community Programs for Clinical Research on AIDS 019 and the AIDS Clinical Trials Group 222 Protocol Team.

Authors:  D C Perlman; W M El Sadr; L B Heifets; E T Nelson; J P Matts; K Chirgwin; N Salomon; E E Telzak; O Klein; B N Kreiswirth; J M Musser; R Hafner
Journal:  AIDS       Date:  1997-10       Impact factor: 4.177

Review 3.  Quinolones in 2005: an update.

Authors:  F Van Bambeke; J-M Michot; J Van Eldere; P M Tulkens
Journal:  Clin Microbiol Infect       Date:  2005-04       Impact factor: 8.067

Review 4.  Mutant selection window hypothesis updated.

Authors:  Karl Drlica; Xilin Zhao
Journal:  Clin Infect Dis       Date:  2007-01-24       Impact factor: 9.079

5.  Type II topoisomerase mutations in ciprofloxacin-resistant strains of Pseudomonas aeruginosa.

Authors:  H Mouneimné; J Robert; V Jarlier; E Cambau
Journal:  Antimicrob Agents Chemother       Date:  1999-01       Impact factor: 5.191

6.  A nucleotide mutation associated with fluoroquinolone resistance observed in gyrA of in vitro obtained Rhodococcus equi mutants.

Authors:  Hidekazu Niwa; Seiji Hobo; Toru Anzai
Journal:  Vet Microbiol       Date:  2006-03-23       Impact factor: 3.293

Review 7.  Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments.

Authors:  Katie L Hopkins; Robert H Davies; E John Threlfall
Journal:  Int J Antimicrob Agents       Date:  2005-05       Impact factor: 5.283

8.  The mutant selection window in rabbits infected with Staphylococcus aureus.

Authors:  Junchang Cui; Youning Liu; Rui Wang; Weihang Tong; Karl Drlica; Xilin Zhao
Journal:  J Infect Dis       Date:  2006-10-20       Impact factor: 5.226

9.  Correlation between quinolone susceptibility patterns and sequences in the A and B subunits of DNA gyrase in mycobacteria.

Authors:  I Guillemin; V Jarlier; E Cambau
Journal:  Antimicrob Agents Chemother       Date:  1998-08       Impact factor: 5.191

10.  Relapsing Rhodococcus equi infection in a heart transplant recipient successfully treated with long-term linezolid.

Authors:  Patricia Muñoz; Jesús Palomo; Jesús Guinea; Juan Yañez; Maddalena Giannella; Emilio Bouza
Journal:  Diagn Microbiol Infect Dis       Date:  2007-10-18       Impact factor: 2.803
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  3 in total

1.  Effect of ciprofloxacin concentration on the frequency and nature of resistant mutants selected from Pseudomonas aeruginosa mutS and mutT hypermutators.

Authors:  Natalia R Morero; Mariela R Monti; Carlos E Argaraña
Journal:  Antimicrob Agents Chemother       Date:  2011-06-06       Impact factor: 5.191

2.  Antimicrobial Resistance Spectrum Conferred by pRErm46 of Emerging Macrolide (Multidrug)-Resistant Rhodococcus equi.

Authors:  Erdal Erol; Mariela Scortti; Jordan Fortner; Mukesh Patel; José A Vázquez-Boland
Journal:  J Clin Microbiol       Date:  2021-07-28       Impact factor: 5.948

Review 3.  Membrane transport systems and the biodegradation potential and pathogenicity of genus Rhodococcus.

Authors:  Carla C C R de Carvalho; Sofia S Costa; Pedro Fernandes; Isabel Couto; Miguel Viveiros
Journal:  Front Physiol       Date:  2014-04-04       Impact factor: 4.566
  3 in total

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