OBJECTIVES: The aim of the present analyses was to examine the association between cortisol, DHEA sulphate (DHEAS) and the cortisol:DHEAS ratio and mortality. DESIGN: This was a prospective cohort analysis. METHODS: Participants were 4255 Vietnam-era US army veterans. From military service files, telephone interviews and a medical examination, occupational, socio-demographic and health data were collected. Contemporary morning fasted cortisol and DHEAS concentrations were determined. Mortality was tracked over the subsequent 15 years. The outcomes were all-cause, cardiovascular disease, cancer, other medical mortality and external causes of death. Cox proportional hazard models were tested, initially with adjustment for age, and then with adjustment for a range of candidate confounders. RESULTS: In general, cortisol concentrations did not show an association with all-cause or cause-specific mortality. However, in age-adjusted and fully adjusted analyses, DHEAS was negatively related to all-cause, all cancers and other medical mortality; high DHEAS concentrations were protective. The cortisol:DHEAS ratio was also associated with these outcomes in both age-adjusted and fully adjusted models; the higher the ratio, the greater the risk of death. CONCLUSIONS: DHEAS was negatively associated, and the ratio of cortisol to DHEAS was positively associated with all-cause, cancer and other medical cause mortality. Further experimental study is needed to elucidate the mechanisms involved in these relationships.
OBJECTIVES: The aim of the present analyses was to examine the association between cortisol, DHEA sulphate (DHEAS) and the cortisol:DHEAS ratio and mortality. DESIGN: This was a prospective cohort analysis. METHODS:Participants were 4255 Vietnam-era US army veterans. From military service files, telephone interviews and a medical examination, occupational, socio-demographic and health data were collected. Contemporary morning fasted cortisol and DHEAS concentrations were determined. Mortality was tracked over the subsequent 15 years. The outcomes were all-cause, cardiovascular disease, cancer, other medical mortality and external causes of death. Cox proportional hazard models were tested, initially with adjustment for age, and then with adjustment for a range of candidate confounders. RESULTS: In general, cortisol concentrations did not show an association with all-cause or cause-specific mortality. However, in age-adjusted and fully adjusted analyses, DHEAS was negatively related to all-cause, all cancers and other medical mortality; high DHEAS concentrations were protective. The cortisol:DHEAS ratio was also associated with these outcomes in both age-adjusted and fully adjusted models; the higher the ratio, the greater the risk of death. CONCLUSIONS:DHEAS was negatively associated, and the ratio of cortisol to DHEAS was positively associated with all-cause, cancer and other medical cause mortality. Further experimental study is needed to elucidate the mechanisms involved in these relationships.
Authors: Tianyi Huang; Elizabeth M Poole; Celine Vetter; Kathryn M Rexrode; Laura D Kubzansky; Eva Schernhammer; Nicolas Rohleder; Frank B Hu; Susan Redline; Shelley S Tworoger Journal: Psychoneuroendocrinology Date: 2017-07-19 Impact factor: 4.905
Authors: Claudine A Blum; Cornelia Mueller; Philipp Schuetz; Felix Fluri; Michael Trummler; Beat Mueller; Mira Katan; Mirjam Christ-Crain Journal: PLoS One Date: 2013-05-01 Impact factor: 3.240
Authors: Kevin N Keane; Peter M Hinchliffe; Navid Namdar; Jason L Conceicao; Philip Newsholme; John L Yovich Journal: Drug Des Devel Ther Date: 2015-10-09 Impact factor: 4.162
Authors: Lauren C Houghton; Renata E Howland; Ying Wei; Xinran Ma; Rebecca D Kehm; Wendy K Chung; Jeanine M Genkinger; Regina M Santella; Michaela F Hartmann; Stefan A Wudy; Mary Beth Terry Journal: Cancer Epidemiol Biomarkers Prev Date: 2020-09-30 Impact factor: 4.090