| Literature DB >> 20498044 |
Yoshiaki Ito1, Naoya Toriuchi, Teruhito Yoshitaka, Hiroe Ueno-Kudoh, Tempei Sato, Shigetoshi Yokoyama, Keiichiro Nishida, Takayuki Akimoto, Michiko Takahashi, Shigeru Miyaki, Hiroshi Asahara.
Abstract
Mohawk (Mkx) is a member of the Three Amino acid Loop Extension superclass of atypical homeobox genes that is expressed in developing tendons. To investigate the in vivo functions of Mkx, we generated Mkx(-/-) mice. These mice had hypoplastic tendons throughout the body. Despite the reduction in tendon mass, the cell number in tail tendon fiber bundles was similar between wild-type and Mkx(-/-) mice. We also observed small collagen fibril diameters and a down-regulation of type I collagen in Mkx(-/-) tendons. These data indicate that Mkx plays a critical role in tendon differentiation by regulating type I collagen production in tendon cells.Entities:
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Year: 2010 PMID： 20498044 PMCID： PMC2890854 DOI： 10.1073/pnas.1000525107
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205