Literature DB >> 2049786

Quercetin-induced lipid peroxidation and DNA damage in isolated rat-liver nuclei.

S C Sahu1, M C Washington.   

Abstract

The extent of lipid peroxidation and DNA damage induced by quercetin were studied under aerobic conditions in isolated rat-liver nuclei. The effects of iron and copper ions on these two toxic oxidative processes were also investigated. Quercetin induced significant (P less than 0.05) concentration-dependent nuclear lipid peroxidation concurrent with DNA degradation; these effects were enhanced by iron and copper ions. The results suggest that the reactive oxygen species generated by quercetin autoxidation, catalyzed by iron and copper ions, are responsible for the concurrent lipid peroxidation and DNA damage in isolated rat-liver nuclei.

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Year:  1991        PMID： 2049786     DOI： 10.1016/0304-3835(91)90026-e

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  4 in total

1.  Free radical generation and lipid peroxidation among the dry cell industry workers exposed to carbon.

Authors:  K K Reddy; T P Reddy; B V Somasekharaiah; K S Kumari
Journal:  Indian J Clin Biochem       Date:  1998-01

2.  Mechanistic evaluation of Ginkgo biloba leaf extract-induced genotoxicity in L5178Y cells.

Authors:  Haixia Lin; Xiaoqing Guo; Suhui Zhang; Stacey L Dial; Lei Guo; Mugimane G Manjanatha; Martha M Moore; Nan Mei
Journal:  Toxicol Sci       Date:  2014-03-04       Impact factor: 4.849

3.  UHPLC-OrbiTrap MS Characterization of Phenolic Profiles in French Marigold Extracts and Analysis of Their Antifeedant Activity against Colorado Potato Beetle.

Authors:  Nina Devrnja; Uroš Gašić; Sanja Šajkunić; Aleksandar Cingel; Sofija Stupar; Ljiljana Tubić; Jelena Savić
Journal:  Plants (Basel)       Date:  2022-02-01

4.  Potential toxicity of quercetin: The repression of mitochondrial copy number via decreased POLG expression and excessive TFAM expression in irradiated murine bone marrow.

Authors:  Ruiqing Chen; Jingan Lin; Jingshen Hong; Deping Han; Addison D Zhang; Ruilong Lan; Lengxi Fu; Zhaoyang Wu; Jianhua Lin; Weijian Zhang; Zeng Wang; Wei Chen; Chun Chen; Hengshan Zhang
Journal:  Toxicol Rep       Date:  2014-07-30
  4 in total

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