Literature DB >> 20496900

Anti-CD4-targeted gold nanoparticles induce specific contrast enhancement of peripheral lymph nodes in X-ray computed tomography of live mice.

Wolfgang Eck1, Anthony I Nicholson, Hanswalter Zentgraf, Wolfhard Semmler, Sönke Bartling.   

Abstract

Antibody-conjugated gold nanoparticles have been applied as a biologically targeted contrast agent in live mice for one of the most widely used medical imaging methods, X-ray computed tomography. Such nanoprobes directed toward the CD4 receptor lead to distinctly enhanced X-ray contrast of peripheral lymph nodes. This study demonstrates the general feasibility of biologically specific X-ray imaging in living animals and discusses basic requirements for the use of nanoparticles as a targeted X-ray contrast agent.

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Year:  2010        PMID： 20496900     DOI： 10.1021/nl101019s

Source DB:  PubMed          Journal:  Nano Lett        ISSN： 1530-6984            Impact factor:   11.189


  28 in total

Review 1.  Nanotechnology for computed tomography: a real potential recently disclosed.

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2.  Labeling monocytes with gold nanoparticles to track their recruitment in atherosclerosis with computed tomography.

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Review 3.  Nanoformulated Antiretrovirals for Penetration of the Central Nervous System: State of the Art.

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Authors:  Randall Toy; Lisa Bauer; Christopher Hoimes; Ketan B Ghaghada; Efstathios Karathanasis
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5.  Gold nanoprobes for theranostics.

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6.  Water-Dispersible Bismuth-Organic Materials with Computed Tomography Contrast Properties.

Authors:  Guoxian Zhang; Pratap C Naha; Prabhat Gautam; David P Cormode; Julian M W Chan
Journal:  ACS Appl Bio Mater       Date:  2018-11-12

7.  Gold nanoparticles in radiation research: potential applications for imaging and radiosensitization.

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Journal:  Transl Cancer Res       Date:  2013-08-01       Impact factor: 1.241

8.  Dextran coated bismuth-iron oxide nanohybrid contrast agents for computed tomography and magnetic resonance imaging.

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Journal:  J Mater Chem B       Date:  2014-12-14       Impact factor: 6.331

9.  Bisphosphonate-functionalized gold nanoparticles for contrast-enhanced X-ray detection of breast microcalcifications.

Authors:  Lisa E Cole; Tracy Vargo-Gogola; Ryan K Roeder
Journal:  Biomaterials       Date:  2013-12-18       Impact factor: 12.479

Review 10.  X-ray-computed tomography contrast agents.

Authors:  Hrvoje Lusic; Mark W Grinstaff
Journal:  Chem Rev       Date:  2012-12-05       Impact factor: 60.622
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