Literature DB >> 20495069

CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.

Santhi Gorantla1, Edward Makarov, Jennifer Finke-Dwyer, Catherine L Gebhart, William Domm, Stephen Dewhurst, Howard E Gendelman, Larisa Y Poluektova.   

Abstract

Stable engraftment of human lymphoid tissue in NOD/scid-IL-2Rgammacnull mice after CD34+ hematopoietic stem cell reconstitution permits the evaluation of ongoing HIV-1 infection for weeks to months. We demonstrate that HIV-1-infected rodents develop virus-specific cellular immune responses. CD8+ cell depletion, 2 or 5-7 wk after viral infection, resulted in a significant increase of HIV-1 load, robust immune cell activation, and cytopathology in lymphoid tissues but preserved CD4/CD8 double-positive thymic T cell pools. Human CD8+ cells reappeared in circulation as early as 2-3 wk. These data support a role of CD8+ cells in viral surveillance and the relevance of this humanized mouse model for the studies of HIV-1 pathobiology and virus-specific immunity.

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Year:  2010        PMID： 20495069      PMCID： PMC3008566          DOI： 10.4049/jimmunol.1000438

Source DB:  PubMed          Journal:  J Immunol        ISSN： 0022-1767            Impact factor:   5.422


  53 in total

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2.  Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1.

Authors:  Michael W Melkus; Jacob D Estes; Angela Padgett-Thomas; Joel Gatlin; Paul W Denton; Florence A Othieno; Anja K Wege; Ashley T Haase; J Victor Garcia
Journal:  Nat Med       Date:  2006-10-22       Impact factor: 53.440

3.  Reconstitution of a functional human immune system in immunodeficient mice through combined human fetal thymus/liver and CD34+ cell transplantation.

Authors:  Ping Lan; Noriko Tonomura; Akira Shimizu; Shumei Wang; Yong-Guang Yang
Journal:  Blood       Date:  2006-01-12       Impact factor: 22.113

4.  Durable protection of rhesus macaques immunized with a replicating adenovirus-SIV multigene prime/protein boost vaccine regimen against a second SIVmac251 rectal challenge: role of SIV-specific CD8+ T cell responses.

Authors:  Nina V Malkevitch; L Jean Patterson; M Kristine Aldrich; Yichen Wu; David Venzon; Ruth H Florese; V S Kalyanaraman; Ranajit Pal; Eun Mi Lee; Jun Zhao; Anthony Cristillo; Marjorie Robert-Guroff
Journal:  Virology       Date:  2006-06-30       Impact factor: 3.616

5.  Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes.

Authors:  J E Schmitz; M J Kuroda; S Santra; V G Sasseville; M A Simon; M A Lifton; P Racz; K Tenner-Racz; M Dalesandro; B J Scallon; J Ghrayeb; M A Forman; D C Montefiori; E P Rieber; N L Letvin; K A Reimann
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6.  Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice.

Authors:  Fumihiko Ishikawa; Masaki Yasukawa; Bonnie Lyons; Shuro Yoshida; Toshihiro Miyamoto; Goichi Yoshimoto; Takeshi Watanabe; Koichi Akashi; Leonard D Shultz; Mine Harada
Journal:  Blood       Date:  2005-05-26       Impact factor: 22.113

7.  Disseminated and sustained HIV infection in CD34+ cord blood cell-transplanted Rag2-/-gamma c-/- mice.

Authors:  Stefan Baenziger; Roxane Tussiwand; Erika Schlaepfer; Luca Mazzucchelli; Mathias Heikenwalder; Michael O Kurrer; Silvia Behnke; Joachim Frey; Annette Oxenius; Helen Joller; Adriano Aguzzi; Markus G Manz; Roberto F Speck
Journal:  Proc Natl Acad Sci U S A       Date:  2006-10-12       Impact factor: 11.205

8.  Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 challenge.

Authors:  Santhi Gorantla; Kathlyn Santos; Vakara Meyer; Stephen Dewhurst; William J Bowers; Howard J Federoff; Howard E Gendelman; Larisa Poluektova
Journal:  J Virol       Date:  2005-02       Impact factor: 5.103

9.  CD8+ lymphocytes do not mediate protection against acute superinfection 20 days after vaccination with a live attenuated simian immunodeficiency virus.

Authors:  Richard Stebbings; Neil Berry; Herman Waldmann; Pru Bird; Geoff Hale; Jim Stott; David North; Robin Hull; Joanna Hall; Jenny Lines; Stuart Brown; Nikki D'Arcy; Leanne Davis; William Elsley; Cherry Edwards; Deborah Ferguson; Jane Allen; Neil Almond
Journal:  J Virol       Date:  2005-10       Impact factor: 5.103

10.  Dramatic rise in plasma viremia after CD8(+) T cell depletion in simian immunodeficiency virus-infected macaques.

Authors:  X Jin; D E Bauer; S E Tuttleton; S Lewin; A Gettie; J Blanchard; C E Irwin; J T Safrit; J Mittler; L Weinberger; L G Kostrikis; L Zhang; A S Perelson; D D Ho
Journal:  J Exp Med       Date:  1999-03-15       Impact factor: 14.307
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  54 in total

Review 1.  Humanized mouse models for HIV-1 infection of the CNS.

Authors:  Jenna B Honeycutt; Patricia A Sheridan; Glenn K Matsushima; J Victor Garcia
Journal:  J Neurovirol       Date:  2014-11-04       Impact factor: 2.643

2.  Human tumor xenografts: the good, the bad, and the ugly.

Authors:  Richard A Morgan
Journal:  Mol Ther       Date:  2012-05       Impact factor: 11.454

Review 3.  HIV-1 immunopathogenesis in humanized mouse models.

Authors:  Liguo Zhang; Lishan Su
Journal:  Cell Mol Immunol       Date:  2012-04-16       Impact factor: 11.530

Review 4.  Rodent models for HIV-associated neurocognitive disorders.

Authors:  Santhi Gorantla; Larisa Poluektova; Howard E Gendelman
Journal:  Trends Neurosci       Date:  2012-02-01       Impact factor: 13.837

5.  A doxycycline-dependent human immunodeficiency virus type 1 replicates in vivo without inducing CD4+ T-cell depletion.

Authors:  Nicolas Legrand; Gisela J van der Velden; Raphaël Ho Tsong Fang; Marc Douaisi; Kees Weijer; Atze T Das; Bianca Blom; Christel H Uittenbogaart; Ben Berkhout; Mireille Centlivre
Journal:  J Gen Virol       Date:  2012-05-30       Impact factor: 3.891

6.  Human hepatocytes and hematolymphoid dual reconstitution in treosulfan-conditioned uPA-NOG mice.

Authors:  Tanuja L Gutti; Jaclyn S Knibbe; Edward Makarov; Jinjin Zhang; Govardhana R Yannam; Santhi Gorantla; Yimin Sun; David F Mercer; Hiroshi Suemizu; James L Wisecarver; Natalia A Osna; Tatiana K Bronich; Larisa Y Poluektova
Journal:  Am J Pathol       Date:  2013-11-06       Impact factor: 4.307

7.  Loss of neuronal integrity during progressive HIV-1 infection of humanized mice.

Authors:  Prasanta K Dash; Santhi Gorantla; Howard E Gendelman; Jaclyn Knibbe; George P Casale; Edward Makarov; Adrian A Epstein; Harris A Gelbard; Michael D Boska; Larisa Y Poluektova
Journal:  J Neurosci       Date:  2011-03-02       Impact factor: 6.167

8.  Manganese-Enhanced Magnetic Resonance Imaging Reflects Brain Pathology During Progressive HIV-1 Infection of Humanized Mice.

Authors:  Aditya N Bade; Santhi Gorantla; Prasanta K Dash; Edward Makarov; Balasrinivasa R Sajja; Larisa Y Poluektova; Jiangtao Luo; Howard E Gendelman; Michael D Boska; Yutong Liu
Journal:  Mol Neurobiol       Date:  2015-06-11       Impact factor: 5.590

9.  Humanized NOG mice as a model for tuberculosis vaccine-induced immunity: a comparative analysis with the mouse and guinea pig models of tuberculosis.

Authors:  Ajay Grover; Amber Troy; Jenny Rowe; JoLynn M Troudt; Elizabeth Creissen; Jennifer McLean; Prabal Banerjee; Gerold Feuer; Angelo A Izzo
Journal:  Immunology       Date:  2017-06-19       Impact factor: 7.397

Review 10.  Humanized mice for HIV and AIDS research.

Authors:  J Victor Garcia
Journal:  Curr Opin Virol       Date:  2016-07-19       Impact factor: 7.090
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