Literature DB >> 20494992

Structure-activity analysis of the Pseudomonas quinolone signal molecule.

James Hodgkinson1, Steven D Bowden, Warren R J D Galloway, David R Spring, Martin Welch.   

Abstract

We synthesized a range of PQS (Pseudomonas quinolone signal; 2-heptyl-3-hydroxy-4(1H)-quinolone) analogues and tested them for their ability to stimulate MvfR-dependent pqsA transcription, MvfR-independent pyoverdine production, and membrane vesicle production. The structure-activity profile of the PQS analogues was different for each of these phenotypes. Certain inactive PQS analogues were also found to strongly synergize PQS-dependent pyoverdine production.

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Year:  2010        PMID： 20494992      PMCID： PMC2897350          DOI： 10.1128/JB.00081-10

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  26 in total

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9.  A stable isotope dilution assay for the quantification of the Pseudomonas quinolone signal in Pseudomonas aeruginosa cultures.

Authors:  F Lépine; E Déziel; S Milot; L G Rahme
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