Literature DB >> 20494120

Regulation of the activity of 5-lipoxygenase, a key enzyme in leukotriene biosynthesis.

Olof Rådmark1, Bengt Samuelsson.   

Abstract

5-Lipoxygenase (5LO) catalyzes two steps in the biosynthesis of leukotrienes (LTs), lipid mediators of inflammation derived from arachidonic acid. LTs function in normal host defense, and have pathophysiological roles in chronic inflammatory diseases as asthma and atherosclerosis. Also, possible effects of 5LO products in relation to tumorigenesis have been described. Thus, insight regarding the biochemistry of 5LO is relevant for better understanding of normal physiology, and for development of therapy. 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20494120     DOI： 10.1016/j.bbrc.2010.02.173

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  51 in total

1.  Effects of gender on gene expression in the blood of ischemic stroke patients.

Authors:  Yingfang Tian; Boryana Stamova; Glen C Jickling; Dazhi Liu; Bradley P Ander; Cheryl Bushnell; Xinhua Zhan; Ryan R Davis; Piero Verro; William C Pevec; Nasim Hedayati; David L Dawson; Jane Khoury; Edward C Jauch; Arthur Pancioli; Joseph P Broderick; Frank R Sharp
Journal:  J Cereb Blood Flow Metab       Date:  2011-12-14       Impact factor: 6.200

Review 2.  Anti-inflammatory therapies for atherosclerosis.

Authors:  Magnus Bäck; Göran K Hansson
Journal:  Nat Rev Cardiol       Date:  2015-02-10       Impact factor: 32.419

3.  Mechanisms for anti-inflammatory effects of 1-[15(S)-hydroxyeicosapentaenoyl] lysophosphatidylcholine, administered intraperitoneally, in zymosan A-induced peritonitis.

Authors:  Nguyen Dang Hung; Mee Ree Kim; Dai-Eun Sok
Journal:  Br J Pharmacol       Date:  2011-03       Impact factor: 8.739

4.  Hypertonic saline inhibits arachidonic acid priming of the human neutrophil oxidase.

Authors:  Luis Lee; Marguerite R Kelher; Ernest E Moore; Anirban Banerjee; Christopher C Silliman
Journal:  J Surg Res       Date:  2011-07-14       Impact factor: 2.192

5.  Redundant and Cooperative Roles for Yersinia pestis Yop Effectors in the Inhibition of Human Neutrophil Exocytic Responses Revealed by Gain-of-Function Approach.

Authors:  Amanda R Pulsifer; Aruna Vashishta; Shane A Reeves; Jennifer K Wolfe; Samantha G Palace; Megan K Proulx; Jon Goguen; Sobha R Bodduluri; Bodduluri Haribabu; Silvia M Uriarte; Matthew B Lawrenz
Journal:  Infect Immun       Date:  2020-02-20       Impact factor: 3.441

6.  Method to Visualize and Analyze Membrane Interacting Proteins by Transmission Electron Microscopy.

Authors:  Ramakrishnan B Kumar; Lin Zhu; Hans Hebert; Caroline Jegerschöld
Journal:  J Vis Exp       Date:  2017-03-05       Impact factor: 1.355

Review 7.  New families of bioactive oxidized phospholipids generated by immune cells: identification and signaling actions.

Authors:  Valerie B O'Donnell; Robert C Murphy
Journal:  Blood       Date:  2012-07-16       Impact factor: 22.113

Review 8.  Novel Key Players in the Development of Tau Neuropathology: Focus on the 5-Lipoxygenase.

Authors:  Elisabetta Lauretti; Domenico Praticò
Journal:  J Alzheimers Dis       Date:  2018       Impact factor: 4.472

Review 9.  Leukotrienes in pulmonary arterial hypertension.

Authors:  Wen Tian; Xinguo Jiang; Yon K Sung; Jin Qian; Ke Yuan; Mark R Nicolls
Journal:  Immunol Res       Date:  2014-05       Impact factor: 2.829

Review 10.  Mammalian lipoxygenases and their biological relevance.

Authors:  Hartmut Kuhn; Swathi Banthiya; Klaus van Leyen
Journal:  Biochim Biophys Acta       Date:  2014-10-12
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