Anna Gniatkowska-Nowakowska1. 1. Outpatient Clinic of Child Neurology and Epileptology, 25-565 Kielce, Kościuszki Str. No. 52/012, Poland. ankagn@mp.pl
Abstract
PURPOSE: To describe a greater risk of fractures (about 2-6 times more often) in epilepsy children than in children without epilepsy. METHODS: This article describe 126 epilepsy children in age 7-16 who were treated with Antiepileptic Drugs (AEDs) in mono and add-on therapy during 5 years. In the control group were 132 children in age 7-16 without epilepsy and not treated with AEDs, observed in Outpatient Clinic due to headache for 5 years. In both groups we measured bone mineral density (BMD), the calcium and phosphate levels in blood and urine and frequency of fractures. We analyzed both groups statistically (Mann-Whitney test). RESULT: The frequency of fractures is 2-3 times greater in children with epilepsy then in the control group. Osteoporosis and osteopenia is more often present in children who have taken AEDs. Differences in calcium and phosphate levels in blood and urine between study and control group are statistically significant (p<0.001). CONCLUSION: Fractures are an important adverse effect in children who are taking AEDs. 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
PURPOSE: To describe a greater risk of fractures (about 2-6 times more often) in epilepsychildren than in children without epilepsy. METHODS: This article describe 126 epilepsychildren in age 7-16 who were treated with Antiepileptic Drugs (AEDs) in mono and add-on therapy during 5 years. In the control group were 132 children in age 7-16 without epilepsy and not treated with AEDs, observed in Outpatient Clinic due to headache for 5 years. In both groups we measured bone mineral density (BMD), the calcium and phosphate levels in blood and urine and frequency of fractures. We analyzed both groups statistically (Mann-Whitney test). RESULT: The frequency of fractures is 2-3 times greater in children with epilepsy then in the control group. Osteoporosis and osteopenia is more often present in children who have taken AEDs. Differences in calcium and phosphate levels in blood and urine between study and control group are statistically significant (p<0.001). CONCLUSION:Fractures are an important adverse effect in children who are taking AEDs. 2010 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.
Authors: Ara Ko; Juhyun Kong; Furkat Samadov; Akmal Mukhamedov; Young Mi Kim; Yun-Jin Lee; Sang Ook Nam Journal: Ann Pediatr Endocrinol Metab Date: 2020-03-31