Literature DB >> 20493696

Structure-activity relationship (SAR) investigations of tetrahydroquinolines as BKCa agonists.

Vijay K Gore1, Vu V Ma, Ruoyuan Yin, Joe Ligutti, David Immke, Elizabeth M Doherty, Mark H Norman.   

Abstract

The membrane bound large-conductance, calcium-activated potassium channel (BKCa) is an important regulator of neuronal activity. Here we describe the identification and structure-activity relationship of a novel class of potent tetrahydroquinoline BKCa agonists. An example from this class of BKCa agonists was shown to depress the spontaneous neuronal discharges in an electrophysiological model of migraine. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20493696     DOI： 10.1016/j.bmcl.2010.04.125

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Microwave-assisted Expeditious and Efficient Synthesis of Cyclopentene Ring-fused Tetrahydroquinoline Derivatives Using Three-component Povarov Reaction.

Authors:  Abhijit R Kulkarni; Ganesh A Thakur
Journal:  Tetrahedron Lett       Date:  2013-11-27       Impact factor: 2.415

Review 2.  BK channel activators and their therapeutic perspectives.

Authors:  Bo H Bentzen; Søren-Peter Olesen; Lars C B Rønn; Morten Grunnet
Journal:  Front Physiol       Date:  2014-10-09       Impact factor: 4.566

3.  Kinetic resolution of racemic 2-substituted 1,2-dihydroquinolines via asymmetric Cu-catalyzed borylation.

Authors:  Duanyang Kong; Suna Han; Rui Wang; Meina Li; Guofu Zi; Guohua Hou
Journal:  Chem Sci       Date:  2017-04-19       Impact factor: 9.825

4.  Gold-Catalyzed Hydroalkoxylation/Povarov Reaction Cascade of Alkynols with N-Aryl Imines: Synthesis of Tetrahydroquinolines.

Authors:  Ciwang He; Ju Cai; Yang Zheng; Chao Pei; Lihua Qiu; Xinfang Xu
Journal:  ACS Omega       Date:  2019-09-09

5.  Synthesis of highly substituted tetrahydroquinolines using ethyl cyanoacetate via aza-Michael-Michael addition.

Authors:  Arunan Palanimuthu; Chinpiao Chen; Gene-Hsian Lee
Journal:  RSC Adv       Date:  2020-04-03       Impact factor: 4.036

6.  BKCa Channel Activation Attenuates the Pathophysiological Progression of Monocrotaline-Induced Pulmonary Arterial Hypertension in Wistar Rats.

Authors:  Ana Paula Ferraz; Fernando A C Seara; Emanuelle F Baptista; Thais S Barenco; Thais B B Sottani; Natalia S C Souza; Ainá E Domingos; Raiana A Q Barbosa; Christina M Takiya; Marcos T Couto; Gabriel O Resende; Antonio C Campos de Carvalho; Cristiano G Ponte; Jose Hamilton M Nascimento
Journal:  Cardiovasc Drugs Ther       Date:  2020-11-27       Impact factor: 3.727
  6 in total

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