Literature DB >> 20493037

Acute effects of ammonia on the enzymes of citric acid cycle in rat brain.

L Ratnakumari1, G Y Subbalakshmi, C R Murthy.   

Abstract

Activities of the enzymes of citric acid cycle were determined along with aspartate and alanine aminotransferases and NADP(+)-isocitrate dehydrogenase in the brains of rats treated with an acute dose of ammonium acetate and compared with those of normal animals. Elevation in the activities of pyruvate, ?-ketoglutarate and succinate dehydrogenases and citrate synthase was observed in hyperammonemic animals. The activities of malate, NADP(+)-isocitrate dehydrogenases and aminotransferases decreased under these conditions. The results suggest that ammonia toxicity might not be due to the depletion of ?-ketoglutarate from citric acid cycle.

Entities:  

Year:  1986        PMID： 20493037     DOI： 10.1016/0197-0186(86)90108-7

Source DB:  PubMed          Journal:  Neurochem Int        ISSN： 0197-0186            Impact factor:   3.921


  8 in total

Review 1.  Cerebral energy metabolism in hepatic encephalopathy and hyperammonemia.

Authors:  K V Rao; M D Norenberg
Journal:  Metab Brain Dis       Date:  2001-06       Impact factor: 3.584

2.  Differential effects of ammonia and beta-methylene-DL-aspartate on metabolism of glutamate and related amino acids by astrocytes and neurons in primary culture.

Authors:  J C Lai; C R Murthy; A J Cooper; E Hertz; L Hertz
Journal:  Neurochem Res       Date:  1989-04       Impact factor: 3.996

3.  Relayed (13)C magnetization transfer: detection of malate dehydrogenase reaction in vivo.

Authors:  Jehoon Yang; Jun Shen
Journal:  J Magn Reson       Date:  2006-11-27       Impact factor: 2.229

4.  Activities of pyruvate dehydrogenase, enzymes of citric acid cycle, and aminotransferases in the subcellular fractions of cerebral cortex in normal and hyperammonemic rats.

Authors:  L Ratnakumari; C R Murthy
Journal:  Neurochem Res       Date:  1989-03       Impact factor: 3.996

5.  Neurotoxicity of ammonia and fatty acids: differential inhibition of mitochondrial dehydrogenases by ammonia and fatty acyl coenzyme A derivatives.

Authors:  J C Lai; A J Cooper
Journal:  Neurochem Res       Date:  1991-07       Impact factor: 3.996

6.  Aspartate aminotransferase, malate dehydrogenase, and pyruvate carboxylase activities in rat cerebral synaptic and nonsynaptic mitochondria: effects of in vitro treatment with ammonia, hyperammonemia and hepatic encephalopathy.

Authors:  L Faff-Michalak; J Albrecht
Journal:  Metab Brain Dis       Date:  1991-12       Impact factor: 3.584

7.  Studying Enzymes by In Vivo C Magnetic Resonance Spectroscopy.

Authors:  Su Xu; Jun Shen
Journal:  Prog Nucl Magn Reson Spectrosc       Date:  2009-10-01       Impact factor: 9.795

8.  Ammonia-induced mitochondrial dysfunction and energy metabolism disturbances in isolated brain and liver mitochondria, and the effect of taurine administration: relevance to hepatic encephalopathy treatment.

Authors:  Hossein Niknahad; Akram Jamshidzadeh; Reza Heidari; Mahdi Zarei; Mohammad Mehdi Ommati
Journal:  Clin Exp Hepatol       Date:  2017-07-05
  8 in total

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