Literature DB >> 20491108

Molecular modeling, total synthesis, and biological evaluations of C9-deoxy bryostatin 1.

Gary E Keck1, Yam B Poudel, Arnab Rudra, Jeffrey C Stephens, Noemi Kedei, Nancy E Lewin, Megan L Peach, Peter M Blumberg.   

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Year:  2010        PMID： 20491108      PMCID： PMC3269168          DOI： 10.1002/anie.201001200

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


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  21 in total

1.  The practical synthesis of a novel and highly potent analogue of bryostatin.

Authors:  Paul A Wender; Jeremy L Baryza; Chad E Bennett; F Christopher Bi; Stacey E Brenner; Michael O Clarke; Joshua C Horan; Cindy Kan; Emmanuel Lacôte; Blaise Lippa; Peter G Nell; Tim M Turner
Journal:  J Am Chem Soc       Date:  2002-11-20       Impact factor: 15.419

Review 2.  The chemistry and biology of the bryostatin antitumour macrolides.

Authors:  Karl J Hale; Marc G Hummersone; Soraya Manaviazar; Mark Frigerio
Journal:  Nat Prod Rep       Date:  2002-08       Impact factor: 13.423

Review 3.  New approaches to the total synthesis of the bryostatin antitumor macrolides.

Authors:  Karl J Hale; Soraya Manaviazar
Journal:  Chem Asian J       Date:  2010-04-01

4.  Synthetic studies toward the bryostatins: a substrate-controlled approach to the A-ring.

Authors:  Gary E Keck; Dennie S Welch; Paige K Vivian
Journal:  Org Lett       Date:  2006-08-17       Impact factor: 6.005

5.  Efficient synthetic access to a new family of highly potent bryostatin analogues via a Prins-driven macrocyclization strategy.

Authors:  Paul A Wender; Brian A Dechristopher; Adam J Schrier
Journal:  J Am Chem Soc       Date:  2008-05-02       Impact factor: 15.419

6.  Bryostatin 1 induces prolonged activation of extracellular regulated protein kinases in and apoptosis of LNCaP human prostate cancer cells overexpressing protein kinase calpha.

Authors:  J E Gschwend; W R Fair; C T Powell
Journal:  Mol Pharmacol       Date:  2000-06       Impact factor: 4.436

7.  Synthetic Studies Toward Bryostatin 1: Preparation of a C(1)-C(16) Fragment by Pyran Annulation.

Authors:  Gary E Keck; Dennie S Welch; Yam B Poudel
Journal:  Tetrahedron Lett       Date:  2006-11-20       Impact factor: 2.415

8.  Enantioselective formal total synthesis of the antitumor macrolide bryostatin 7.

Authors:  Soraya Manaviazar; Mark Frigerio; Gurpreet S Bhatia; Marc G Hummersone; Abil E Aliev; Karl J Hale
Journal:  Org Lett       Date:  2006-09-28       Impact factor: 6.005

9.  Total synthesis of bryostatin 16 using atom-economical and chemoselective approaches.

Authors:  Barry M Trost; Guangbin Dong
Journal:  Nature       Date:  2008-11-27       Impact factor: 49.962

10.  The bryostatin 1 A-ring acetate is not the critical determinant for antagonism of phorbol ester-induced biological responses.

Authors:  Gary E Keck; Wei Li; Matthew B Kraft; Noemi Kedei; Nancy E Lewin; Peter M Blumberg
Journal:  Org Lett       Date:  2009-06-04       Impact factor: 6.005
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  27 in total

1.  Translating Nature's Library: The Bryostatins and Function-Oriented Synthesis.

Authors:  Paul A Wender; Brian A Loy; Adam J Schrier
Journal:  Isr J Chem       Date:  2011-03-24       Impact factor: 3.333

2.  Total synthesis of bryostatin 1.

Authors:  Gary E Keck; Yam B Poudel; Thomas J Cummins; Arnab Rudra; Jonathan A Covel
Journal:  J Am Chem Soc       Date:  2010-12-22       Impact factor: 15.419

3.  Design, synthesis, and evaluation of potent bryostatin analogs that modulate PKC translocation selectivity.

Authors:  Paul A Wender; Jeremy L Baryza; Stacey E Brenner; Brian A DeChristopher; Brian A Loy; Adam J Schrier; Vishal A Verma
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-17       Impact factor: 11.205

4.  Synthesis and Biological Evaluation of Several Bryostatin Analogues Bearing a Diacylglycerol Lactone C-Ring.

Authors:  David O Baumann; Kevin M McGowan; Noemi Kedei; Megan L Peach; Peter M Blumberg; Gary E Keck
Journal:  J Org Chem       Date:  2016-08-23       Impact factor: 4.354

5.  Synthesis and Biological Evaluation of Fluorescent Bryostatin Analogues.

Authors:  Thomas J Cummins; Noemi Kedei; Agnes Czikora; Nancy E Lewin; Sharon Kirk; Mark E Petersen; Kevin M McGowan; Jin-Qiu Chen; Xiaoling Luo; Randall C Johnson; Sarangan Ravichandran; Peter M Blumberg; Gary E Keck
Journal:  Chembiochem       Date:  2018-03-25       Impact factor: 3.164

6.  Total synthesis of bryostatin 9.

Authors:  Paul A Wender; Adam J Schrier
Journal:  J Am Chem Soc       Date:  2011-05-27       Impact factor: 15.419

7.  The quest for supernatural products: the impact of total synthesis in complex natural products medicinal chemistry.

Authors:  Zhi-Chen Wu; Dale L Boger
Journal:  Nat Prod Rep       Date:  2020-11-10       Impact factor: 13.423

8.  Deletion of the C26 Methyl Substituent from the Bryostatin Analogue Merle 23 Has Negligible Impact on Its Biological Profile and Potency.

Authors:  Xiguang Zhao; Noemi Kedei; Alexandra Michalowski; Nancy E Lewin; Gary E Keck; Peter M Blumberg
Journal:  Chembiochem       Date:  2018-04-27       Impact factor: 3.164

9.  Charge density influences C1 domain ligand affinity and membrane interactions.

Authors:  Jessica S Kelsey; Tamas Geczy; Nancy E Lewin; Noemi Kedei; Colin S Hill; Julia S Selezneva; Christopher J Valle; Wonhee Woo; Inna Gorshkova; Peter M Blumberg
Journal:  Chembiochem       Date:  2014-04-28       Impact factor: 3.164

10.  Evaluation of Chromane-Based Bryostatin Analogues Prepared via Hydrogen-Mediated C-C Bond Formation: Potency Does Not Confer Bryostatin-like Biology.

Authors:  John M Ketcham; Ivan Volchkov; Te-Yu Chen; Peter M Blumberg; Noemi Kedei; Nancy E Lewin; Michael J Krische
Journal:  J Am Chem Soc       Date:  2016-09-27       Impact factor: 15.419
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