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Literature DB >> 2049084

Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains.

T Niwa¹, N Takeda, H Yoshizumi, A Tatematsu, M Yoshida, P Dostert, M Naoi, T Nagatsu.

Abstract

2-Methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline were identified for the first time as novel endogenous amines in parkinsonian and normal human brains by gas chromatography-mass spectrometry. It is of interest that these tetrahydroisoquinolines are analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) which produces Parkinson's disease.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1991 PMID： 2049084 DOI： 10.1016/0006-291x(91)91831-v

Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575

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Cited

10 in total

Review 1. Mitochondrial dysfunction in neurodegeneration.

Authors: J M Cooper; A H Schapira
Journal: J Bioenerg Biomembr Date: 1997-04 Impact factor: 2.945

2. Stereospecific occurrence of a parkinsonism-inducing catechol isoquinoline, N-methyl(R)salsolinol, in the human intraventricular fluid.

Authors: W Maruyama; H Narabayashi; P Dostert; M Naoi
Journal: J Neural Transm (Vienna) Date: 1996 Impact factor: 3.575

3. Cytotoxicity of endogenous isoquinolines to human dopaminergic neuroblastoma SH-SY5Y cells.

Authors: T Takahashi; W Maruyama; Y Deng; P Dostert; D Nakahara; T Niwa; S Ohta; M Naoi
Journal: J Neural Transm (Vienna) Date: 1997 Impact factor: 3.575

Review 4. A possible physiological role for cerebral tetrahydroisoquinolines.

Authors: Jerzy Vetulani; Lucyna Antkiewicz-Michaluk; Irena Nalepa; Mario Sansone
Journal: Neurotox Res Date: 2003 Impact factor: 3.911

Review 5. The tyramine binding site in the central nervous system: an overview.

Authors: A Vaccari
Journal: Neurochem Res Date: 1993-08 Impact factor: 3.996

6. Inhibition of type A and B monoamine oxidase by 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines and their N-methylated derivatives.

Authors: M Minami; W Maruyama; P Dostert; T Nagatsu; M Naoi
Journal: J Neural Transm Gen Sect Date: 1993

Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains.

Review 1. Mitochondrial dysfunction in neurodegeneration.

2. Stereospecific occurrence of a parkinsonism-inducing catechol isoquinoline, N-methyl(R)salsolinol, in the human intraventricular fluid.

3. Cytotoxicity of endogenous isoquinolines to human dopaminergic neuroblastoma SH-SY5Y cells.

Review 4. A possible physiological role for cerebral tetrahydroisoquinolines.

Review 5. The tyramine binding site in the central nervous system: an overview.

6. Inhibition of type A and B monoamine oxidase by 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinolines and their N-methylated derivatives.

7. Naturally-occurring isoquinolines perturb monamine metabolism in the brain: studied by in vivo microdialysis.

8. Oxidative modification of human ceruloplasmin induced by a catechol neurotoxin, salsolinol.

Review 9. Brain sites of movement disorder: genetic and environmental agents in neurodevelopmental perturbations.

10. Tetrahydroisoquinoline derivatives: a new perspective on monoaminergic dysfunction in children with ADHD?