Literature DB >> 204905

The sensitivity of pineal gland beta-receptors appears to be dependent upon calcium ions.

M Wilkinson.   

Abstract

Rat pineals were used in vitro to demonstrate that calcium antagonists induce a hyposensitive response to stimulation of serotonin N-acetyl transferase (NAT) by the beta-agonist isoproterenol or by dibutyryl cyclic AMP. Mn2+, Co2+ and La3+ at 10(-3)M all significantly reduce the effects of isoproterenol stimulation. In addition, the two enantiomers of D600 also inhibit NAT induction, the D-form slightly more effectively than the L-form. Interestingly, La3+ is also able to inhibit NAT after DBcAMP, indicating that Ca2+ can also control enzyme induction at an intracellular site beyond the beta-receptor.

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Year:  1978        PMID： 204905     DOI： 10.1007/bf00584863

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  9 in total

1.  Ca-2+/Mg-2+-dependent cyclic nucleotide phosphodiesterase and its activator protein.

Authors:  S Kakiuchi; R Yamazaki; Y Teshima; K Uenishi; E Miyamoto
Journal:  Adv Cyclic Nucleotide Res       Date:  1975

2.  Rat pineal adenosine cyclic 3',5'-monophosphate phosphodiesterase activity: modulation in vivo by a beta adrenergic receptor.

Authors:  M A Oleshansky; N H Neff
Journal:  Mol Pharmacol       Date:  1975-09       Impact factor: 4.436

3.  Postsynaptic induction of serotonin N-acetyltransferase activity and the control of cyclic nucleotide metabolism in organ cultures of the rat pineal.

Authors:  K P Minneman
Journal:  Mol Pharmacol       Date:  1977-07       Impact factor: 4.436

4.  Inhibition of the noradrenergic induction of pineal N-acetyltransferase by dibutyryl cyclic guanosine monophosphate and by ionophore X-537A.

Authors:  M Wilkinson
Journal:  Neurosci Lett       Date:  1976-03       Impact factor: 3.046

Review 5.  Adrenergic receptors.

Authors:  D J Triggle
Journal:  Annu Rev Pharmacol       Date:  1972       Impact factor: 13.820

6.  Effects on the isolated neurohypophysis of agents which affect the membrane permeability to calcium.

Authors:  J J Dreifuss; J D Grau; J J Nordmann
Journal:  J Physiol       Date:  1973-06       Impact factor: 5.182

7.  Nerve growth factor receptor binding. Influence of enzymes, ions, and protein reagents.

Authors:  S P Banerjee; P Cuatrecasas; S H Snyder
Journal:  J Biol Chem       Date:  1975-02-25       Impact factor: 5.157

8.  Adrenergic-adenosine 3',5'-monophosphate regulation of serotonin N-acetyltransferase activity and the temporal relationship of serotonin N-acetyltransferase activity synthesis of 3H-N-acetylserotonin and 3H-melatonin in the cultured rat pineal gland.

Authors:  D Klein; J L Weller
Journal:  J Pharmacol Exp Ther       Date:  1973-09       Impact factor: 4.030

9.  Modulation in the sensitivity of noradrenergic receptors in the CNS studied by the responsiveness of the cyclic AMP system.

Authors:  M Baudry; M P Martres; J C Schwartz
Journal:  Brain Res       Date:  1976-10-29       Impact factor: 3.252
  9 in total
  1 in total

1.  Possible mechanisms of inhibition and activation of rat N-acetyltransferase (EC 2.3.1.5.) by cations.

Authors:  D J Morton
Journal:  J Neural Transm       Date:  1989       Impact factor: 3.575
  1 in total

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