| Literature DB >> 20488702 |
Tang Peng Cho1, Yang Fang Long, Lin Zhi Gang, Wang Yang, Lu He Jun, Shen Guang Yuan, Fu Jian Hong, Wang Lin, Guan Dong Liang, Zhang Lei, Luo Jing Jing, Gong Ai Shen, She Gao Hong, Wang Dan, Feng Ying, Yan Pang Ke, Leng Ying, Feng Jun, Mong Xian Tai.
Abstract
A series of novel azobicyclo[3.3.0]octane derivatives were synthesized and evaluated as dipeptidyl peptidase 4 (DPP-4) inhibitors. The effort resulted in the discovery of inhibitor 2a, which exhibited excellent efficacies in an oral glucose tolerance test. Introduction of methyl group (2j) could prolong the inhibition of serum DPP-4 activity. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20488702 DOI： 10.1016/j.bmcl.2010.04.120
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823