Literature DB >> 20488547

COMT and anxiety and cognition in children with chromosome 22q11.2 deletion syndrome.

Vandana Shashi1, Timothy D Howard, Matcheri S Keshavan, Jessica Kaczorowski, Margaret N Berry, Kelly Schoch, Edward J Spence, Thomas R Kwapil.   

Abstract

The COMT gene is thought to contribute to the cognitive/psychiatric phenotypes in 22q11.2 deletion syndrome. We measured these manifestations against the Val/Met alleles of the COMT gene, in 40 nonpsychotic 22q11DS children. The Val allele was associated with poor IQ, processing speed, executive function and a higher frequency of anxiety disorders, underscoring the importance of the COMT gene in the childhood psychopathology in 22q11DS. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

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Year:  2010        PMID： 20488547      PMCID： PMC3645485          DOI： 10.1016/j.psychres.2010.04.048

Source DB:  PubMed          Journal:  Psychiatry Res        ISSN： 0165-1781            Impact factor:   3.222


  43 in total

1.  A highly significant association between a COMT haplotype and schizophrenia.

Authors:  Sagiv Shifman; Michal Bronstein; Meira Sternfeld; Anne Pisanté-Shalom; Efrat Lev-Lehman; Avraham Weizman; Ilya Reznik; Baruch Spivak; Nimrod Grisaru; Leon Karp; Richard Schiffer; Moshe Kotler; Rael D Strous; Marnina Swartz-Vanetik; Haim Y Knobler; Eilat Shinar; Jacques S Beckmann; Benjamin Yakir; Neil Risch; Naomi B Zak; Ariel Darvasi
Journal:  Am J Hum Genet       Date:  2002-10-25       Impact factor: 11.025

2.  Catechol O-methyltransferase val158met genotype and neural mechanisms related to affective arousal and regulation.

Authors:  Emily M Drabant; Ahmad R Hariri; Andreas Meyer-Lindenberg; Karen E Munoz; Venkata S Mattay; Bhaskar S Kolachana; Michael F Egan; Daniel R Weinberger
Journal:  Arch Gen Psychiatry       Date:  2006-12

3.  COMT Val108/158 Met modifies mismatch negativity and cognitive function in 22q11 deletion syndrome.

Authors:  Kate Baker; Torsten Baldeweg; Sinthuja Sivagnanasundaram; Peter Scambler; David Skuse
Journal:  Biol Psychiatry       Date:  2005-07-01       Impact factor: 13.382

4.  Risk factors for the emergence of psychotic disorders in adolescents with 22q11.2 deletion syndrome.

Authors:  Doron Gothelf; Carl Feinstein; Tracy Thompson; Eugene Gu; Lauren Penniman; Ellen Van Stone; Hower Kwon; Stephan Eliez; Allan L Reiss
Journal:  Am J Psychiatry       Date:  2007-04       Impact factor: 18.112

5.  Adolescents and young adults with 22q11 deletion syndrome: psychopathology in an at-risk group.

Authors:  Kate D Baker; David H Skuse
Journal:  Br J Psychiatry       Date:  2005-02       Impact factor: 9.319

6.  Meta-analysis of association between a catechol-O-methyltransferase gene polymorphism and attention deficit hyperactivity disorder.

Authors:  Daniel Ka Leung Cheuk; Virginia Wong
Journal:  Behav Genet       Date:  2006-09       Impact factor: 2.805

7.  COMT genotype predicts longitudinal cognitive decline and psychosis in 22q11.2 deletion syndrome.

Authors:  Doron Gothelf; Stephan Eliez; Tracy Thompson; Christine Hinard; Lauren Penniman; Carl Feinstein; Hower Kwon; Shuting Jin; Booil Jo; Stylianos E Antonarakis; Michael A Morris; Allan L Reiss
Journal:  Nat Neurosci       Date:  2005-10-23       Impact factor: 24.884

8.  Cognitive correlates of a functional COMT polymorphism in children with 22q11.2 deletion syndrome.

Authors:  V Shashi; M S Keshavan; T D Howard; M N Berry; M J Basehore; E Lewandowski; T R Kwapil
Journal:  Clin Genet       Date:  2006-03       Impact factor: 4.438

9.  No evidence for an effect of COMT Val158Met genotype on executive function in patients with 22q11 deletion syndrome.

Authors:  Bronwyn Glaser; Martin Debbane; Christine Hinard; Michael A Morris; Sophie P Dahoun; Stylianos E Antonarakis; Stephan Eliez
Journal:  Am J Psychiatry       Date:  2006-03       Impact factor: 18.112

10.  A gender-moderated effect of a functional COMT polymorphism on prefrontal brain morphology and function in velo-cardio-facial syndrome (22q11.2 deletion syndrome).

Authors:  Wendy R Kates; Kevin M Antshel; Nuria Abdulsabur; Deirdre Colgan; Birgit Funke; Wanda Fremont; Anne Marie Higgins; Raju Kucherlapati; Robert J Shprintzen
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2006-04-05       Impact factor: 3.568
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  8 in total

1.  A second look: no effect of the COMT Val158Met polymorphism on conflict adaptation in youth with chromosome 22q11.2 deletion syndrome.

Authors:  Joel Stoddard; Yukari Takarae; Tony J Simon
Journal:  Schizophr Res       Date:  2012-01-14       Impact factor: 4.939

2.  Discordance in Diagnoses and Treatment of Psychiatric Disorders in Children and Adolescents with 22q11.2 Deletion Syndrome.

Authors:  Andrea S Young; Vandana Shashi; Kelly Schoch; Thomas Kwapil; Stephen R Hooper
Journal:  Asian J Psychiatr       Date:  2011-06-01

3.  Association of the family environment with behavioural and cognitive outcomes in children with chromosome 22q11.2 deletion syndrome.

Authors:  T M Allen; J Hersh; K Schoch; K Curtiss; S R Hooper; V Shashi
Journal:  J Intellect Disabil Res       Date:  2013-06-07

4.  Increased corpus callosum volume in children with chromosome 22q11.2 deletion syndrome is associated with neurocognitive deficits and genetic polymorphisms.

Authors:  Vandana Shashi; Alan Francis; Stephen R Hooper; Peter G Kranz; Michael Zapadka; Kelly Schoch; Edward Ip; Neeraj Tandon; Timothy D Howard; Matcheri S Keshavan
Journal:  Eur J Hum Genet       Date:  2012-06-27       Impact factor: 4.246

5.  Is child intelligence associated with parent and sibling intelligence in individuals with developmental disorders? An investigation in youth with 22q11.2 deletion (velo-cardio-facial) syndrome.

Authors:  Amy K Olszewski; Petya D Radoeva; Wanda Fremont; Wendy R Kates; Kevin M Antshel
Journal:  Res Dev Disabil       Date:  2014-09-20

6.  Applicability of the nonverbal learning disability paradigm for children with 22q11.2 deletion syndrome.

Authors:  Kelly Schoch; Waverly Harrell; Stephen R Hooper; Edward H Ip; Santiago Saldana; Thomas R Kwapil; Vandana Shashi
Journal:  J Learn Disabil       Date:  2012-05-09

7.  Adolescence is the starting point of sex-dichotomous COMT genetic effects.

Authors:  S Sannino; M C Padula; F Managò; M Schaer; M Schneider; M Armando; E Scariati; F Sloan-Bena; M Mereu; M Pontillo; S Vicari; G Contarini; C Chiabrera; M Pagani; A Gozzi; S Eliez; F Papaleo
Journal:  Transl Psychiatry       Date:  2017-05-30       Impact factor: 6.222

8.  Dysregulation of DGCR6 and DGCR6L: psychopathological outcomes in chromosome 22q11.2 deletion syndrome.

Authors:  R Das Chakraborty; D Chakraborty; A J Bernal; K Schoch; T D Howard; E H Ip; S R Hooper; M S Keshavan; R L Jirtle; V Shashi
Journal:  Transl Psychiatry       Date:  2012-04-24       Impact factor: 6.222
  8 in total

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