Emil F Coccaro1. 1. Clinical Neuroscience and Psychopharmacology Research Unit, Department of Psychiatry and Behavioral Neuroscience, The Pritzker School of Medicine, The University of Chicago, 5841 South Maryland Avenue, Chicago, IL 60637, USA. ecoccaro@yoda.bsd.uchicago.edu.
Abstract
BACKGROUND: Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and impulsivity are under genetic influence, IED may be familial. METHODS: Blinded and controlled family history study of IED and co-morbid conditions in an outpatient clinical research center for impulsive aggression. The subjects were first-degree relatives of individuals who did and did not meet criteria for IED by DSM-IV and Research Criteria. RESULTS: Elevated Morbid Risk of IED was observed in relatives of IED Probands compared with relatives of Non-IED Probands. This familial signal of IED was not affected by comorbidity in the IED Probands of comorbidity in the relatives of the IED Probands. CONCLUSIONS: IED, as defined by research criteria, appears to be familial and may not be an artifact of other co-morbid conditions.
BACKGROUND:Intermittent Explosive Disorder (IED) is newly appreciated as a commonly occurring disorder of impulsive aggression. Since aggression and impulsivity are under genetic influence, IED may be familial. METHODS: Blinded and controlled family history study of IED and co-morbid conditions in an outpatient clinical research center for impulsive aggression. The subjects were first-degree relatives of individuals who did and did not meet criteria for IED by DSM-IV and Research Criteria. RESULTS: Elevated Morbid Risk of IED was observed in relatives of IED Probands compared with relatives of Non-IED Probands. This familial signal of IED was not affected by comorbidity in the IED Probands of comorbidity in the relatives of the IED Probands. CONCLUSIONS: IED, as defined by research criteria, appears to be familial and may not be an artifact of other co-morbid conditions.
Authors: Katherine M Keyes; Katie A McLaughlin; Thomas Vo; Todd Galbraith; Richard G Heimberg Journal: Depress Anxiety Date: 2015-09-30 Impact factor: 6.505
Authors: Katie A McLaughlin; Jennifer Greif Green; Irving Hwang; Nancy A Sampson; Alan M Zaslavsky; Ronald C Kessler Journal: Arch Gen Psychiatry Date: 2012-11