Literature DB >> 20485538

Learning structurally consistent undirected probabilistic graphical models.

Sushmita Roy1, Terran Lane, Margaret Werner-Washburne.   

Abstract

In many real-world domains, undirected graphical models such as Markov random fields provide a more natural representation of the statistical dependency structure than directed graphical models. Unfortunately, structure learning of undirected graphs using likelihood-based scores remains difficult because of the intractability of computing the partition function. We describe a new Markov random field structure learning algorithm, motivated by canonical parameterization of Abbeel et al. We provide computational improvements on their parameterization by learning per-variable canonical factors, which makes our algorithm suitable for domains with hundreds of nodes. We compare our algorithm against several algorithms for learning undirected and directed models on simulated and real datasets from biology. Our algorithm frequently outperforms existing algorithms, producing higher-quality structures, suggesting that enforcing consistency during structure learning is beneficial for learning undirected graphs.

Entities:  

Year:  2009        PMID: 20485538      PMCID: PMC2872253          DOI: 10.1145/1553374.1553490

Source DB:  PubMed          Journal:  Proc Int Conf Mach Learn


  3 in total

1.  Characterization of differentiated quiescent and nonquiescent cells in yeast stationary-phase cultures.

Authors:  Anthony D Aragon; Angelina L Rodriguez; Osorio Meirelles; Sushmita Roy; George S Davidson; Phillip H Tapia; Chris Allen; Ray Joe; Don Benn; Margaret Werner-Washburne
Journal:  Mol Biol Cell       Date:  2008-01-16       Impact factor: 4.138

2.  ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context.

Authors:  Adam A Margolin; Ilya Nemenman; Katia Basso; Chris Wiggins; Gustavo Stolovitzky; Riccardo Dalla Favera; Andrea Califano
Journal:  BMC Bioinformatics       Date:  2006-03-20       Impact factor: 3.169

3.  A system for generating transcription regulatory networks with combinatorial control of transcription.

Authors:  Sushmita Roy; Margaret Werner-Washburne; Terran Lane
Journal:  Bioinformatics       Date:  2008-04-08       Impact factor: 6.937

  3 in total
  1 in total

1.  Predictive regulatory models in Drosophila melanogaster by integrative inference of transcriptional networks.

Authors:  Daniel Marbach; Sushmita Roy; Ferhat Ay; Patrick E Meyer; Rogerio Candeias; Tamer Kahveci; Christopher A Bristow; Manolis Kellis
Journal:  Genome Res       Date:  2012-03-28       Impact factor: 9.043

  1 in total

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