Literature DB >> 20485323

Bedside-to-bench pharmacology: a complementary concept to translational pharmacology.

J Lötsch1, G Geisslinger.   

Abstract

Translational pharmacology is contemporary; it efficiently covers the progress of research from cellular and animal experiments to the patient. Its logical reasoning is deductive by definition. Abductive reasoning in pharmacological research is often placed second. Although straightforward processes might suit some organizational models, a reasoning process preferring only one direction may sacrifice opportunities. Both directions of reasoning may lead to independent yet comparable or even identical successes, and it is only by using both together that one gains the full benefit of human intellectual resources.

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Year:  2010        PMID: 20485323     DOI: 10.1038/clpt.2010.18

Source DB:  PubMed          Journal:  Clin Pharmacol Ther        ISSN: 0009-9236            Impact factor:   6.875


  5 in total

1.  Drug-target based cross-sectional analysis of olfactory drug effects.

Authors:  Jörn Lötsch; Helena Daiker; Antje Hähner; Alfred Ultsch; Thomas Hummel
Journal:  Eur J Clin Pharmacol       Date:  2015-02-11       Impact factor: 2.953

2.  Pharmacokinetic-pharmacodynamic modeling of the antihypertensive interaction between azilsartan medoxomil and chlorthalidone in spontaneously hypertensive rats.

Authors:  Santosh Kumar Puttrevu; Rachumallu Ramakrishna; Manisha Bhateria; Moon Jain; Kashif Hanif; Rabi Sankar Bhatta
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2017-02-11       Impact factor: 3.000

3.  Translational pharmacokinetic-pharmacodynamic modeling from nonclinical to clinical development: a case study of anticancer drug, crizotinib.

Authors:  Shinji Yamazaki
Journal:  AAPS J       Date:  2012-12-19       Impact factor: 4.009

Review 4.  Complementary Approaches to Existing Target Based Drug Discovery for Identifying Novel Drug Targets.

Authors:  Suhas Vasaikar; Pooja Bhatia; Partap G Bhatia; Koon Chu Yaiw
Journal:  Biomedicines       Date:  2016-11-21

5.  Brain lesion-pattern analysis in patients with olfactory dysfunctions following head trauma.

Authors:  Jörn Lötsch; Alfred Ultsch; Maren Eckhardt; Caroline Huart; Philippe Rombaux; Thomas Hummel
Journal:  Neuroimage Clin       Date:  2016-01-21       Impact factor: 4.881

  5 in total

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