Literature DB >> 20484604

Switching of inferred tropism caused by HIV during interruption of antiretroviral therapy.

L Sarmati1, S G Parisi, C Andreoni, E Nicastri, A R Buonomini, C Boldrin, L Dori, M Montano, C Tommasi, S Andreis, V Vullo, G Palù, M Andreoni.   

Abstract

After interruption of highly active antiretroviral therapy, 15 out of 53 patients with the X4 HIV strain had a significantly larger decrease in CD4(+) T cell count (P = 0.001) and shorter length of treatment interruption (P = 0.02) than patients with the R5 strain. At treatment resumption, HIV inferred tropism switched from the X4 strain to the R5 variant in 9 patients (60%). These patients had a prolonged length of treatment interruption compared to that of those who still carried the X4 strain.

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Year:  2010        PMID： 20484604      PMCID： PMC2897474          DOI： 10.1128/JCM.02125-09

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  18 in total

1.  In vivo HIV-1 infection of CD45RA(+)CD4(+) T cells is established primarily by syncytium-inducing variants and correlates with the rate of CD4(+) T cell decline.

Authors:  H Blaak; A B van't Wout; M Brouwer; B Hooibrink; E Hovenkamp; H Schuitemaker
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-01       Impact factor: 11.205

2.  Clinical and immunological impact of HIV envelope V3 sequence variation after starting initial triple antiretroviral therapy.

Authors:  Zabrina L Brumme; Winnie W Y Dong; Benita Yip; Brian Wynhoven; Noah G Hoffman; Ronald Swanstrom; Mark A Jensen; James I Mullins; Robert S Hogg; Julio S G Montaner; P Richard Harrigan
Journal:  AIDS       Date:  2004-03-05       Impact factor: 4.177

3.  HIV phenotype switching during antiretroviral therapy: emergence of saquinavir-resistant strains with less cytopathogenicity.

Authors:  L Ercoli; L Sarmati; E Nicastri; G Giannini; C Galluzzo; S Vella; M Andreoni
Journal:  AIDS       Date:  1997-08       Impact factor: 4.177

4.  In vivo evolution of human immunodeficiency virus type 1 toward increased pathogenicity through CXCR4-mediated killing of uninfected CD4 T cells.

Authors:  Andreas Jekle; Oliver T Keppler; Erik De Clercq; Dominique Schols; Mark Weinstein; Mark A Goldsmith
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103

5.  Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS.

Authors:  M Koot; I P Keet; A H Vos; R E de Goede; M T Roos; R A Coutinho; F Miedema; P T Schellekens; M Tersmette
Journal:  Ann Intern Med       Date:  1993-05-01       Impact factor: 25.391

6.  Effect of prolonged discontinuation of successful antiretroviral therapy on CD4 T cells: a controlled, prospective trial.

Authors:  Franco Maggiolo; Diego Ripamonti; Gianpietro Gregis; Gianpaolo Quinzan; Annapaola Callegaro; Fredy Suter
Journal:  AIDS       Date:  2004-02-20       Impact factor: 4.177

7.  Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable in all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture.

Authors:  H Schuitemaker; N A Kootstra; R E de Goede; F de Wolf; F Miedema; M Tersmette
Journal:  J Virol       Date:  1991-01       Impact factor: 5.103

8.  Prolonged treatment interruption after immunologic response to highly active antiretroviral therapy.

Authors:  Patrick M Tarwater; Michelle Parish; Joel E Gallant
Journal:  Clin Infect Dis       Date:  2003-11-06       Impact factor: 9.079

9.  Prognostic factors of long-term CD4+count-guided interruption of antiretroviral treatment.

Authors:  L Sarmati; C Andreoni; E Nicastri; C Tommasi; A Buonomini; G D'Ettorre; A Corpolongo; L Dori; M Montano; A Volpi; P Narciso; V Vullo; M Andreoni
Journal:  J Med Virol       Date:  2009-03       Impact factor: 2.327

10.  Improved coreceptor usage prediction and genotypic monitoring of R5-to-X4 transition by motif analysis of human immunodeficiency virus type 1 env V3 loop sequences.

Authors:  Mark A Jensen; Fu-Sheng Li; Angélique B van 't Wout; David C Nickle; Daniel Shriner; Hong-Xia He; Sherry McLaughlin; Raj Shankarappa; Joseph B Margolick; James I Mullins
Journal:  J Virol       Date:  2003-12       Impact factor: 5.103
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  3 in total

1.  HIV-1 coreceptor switch during 2 years of structured treatment interruptions.

Authors:  S Baroncelli; C M Galluzzo; M Andreotti; M F Pirillo; V Fragola; L E Weimer; M Giuliano; S Vella; L Palmisano
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2013-07-04       Impact factor: 3.267

2.  Switch of predicted HIV-1 tropism in treated subjects and its association with disease progression.

Authors:  Antonella Castagna; Laura Monno; Stefania Carta; Laura Galli; Stefania Carrara; Valentina Fedele; Grazia Punzi; Iuri Fanti; Pietro Caramello; Alessandro Cozzi Lepri; Andrea De Luca; Francesca Ceccherini-Silberstein; Antonella d'Arminio Monforte
Journal:  Medicine (Baltimore)       Date:  2016-11       Impact factor: 1.889

3.  A stable CC-chemokine receptor (CCR)-5 tropic virus is correlated with the persistence of HIV RNA at less than 2.5 copies in successfully treated naïve subjects.

Authors:  Saverio Giuseppe Parisi; Samantha Andreis; Carlo Mengoli; Renzo Scaggiante; Mario Cruciani; Roberto Ferretto; Vinicio Manfrin; Sandro Panese; Monica Basso; Caterina Boldrin; Stefania Bressan; Loredana Sarmati; Massimo Andreoni; Giorgio Palù
Journal:  BMC Infect Dis       Date:  2013-07-11       Impact factor: 3.090
  3 in total

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