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Literature DB >> 20484499

Potential for the Anopheles gambiae densonucleosis virus to act as an "evolution-proof" biopesticide.

Abstract

"Evolution-proof" or "late-life-acting" insecticides (LLAIs) preferentially kill older adult mosquitoes and are of extreme interest to control vector-borne diseases such as malaria. We used quantitative PCR to assess whether the Anopheles gambiae densonucleosis virus (AgDNV) had potential as an LLAI. After infection, AgDNV titers increased modestly during larval development but replicated slower than the host cells, resulting in a significant decrease in the normalized virus titer during larval and pupal development. Normalized virus titers dramatically increased after adult emergence, peaking in 7- to 10-day-old adults. Unlike other DNVs, AgDNV does not significantly replicate in preadult mosquitoes but rather preferentially replicates in older adults. The natural dynamics of AgDNV make it ideal for expression of insect-specific toxin genes as a biological LLAI.

Entities: Disease Species

Mesh：

Substances：
DNA, Viral

Year: 2010 PMID： 20484499 PMCID： PMC2897647 DOI： 10.1128/JVI.00631-10

Source DB: PubMed Journal: J Virol ISSN： 0022-538X Impact factor: 5.103

14 in total

1. Aedes aegypti transducing densovirus pathogenesis and expression in Aedes aegypti and Anopheles gambiae larvae.

Authors: T W Ward; M S Jenkins; B N Afanasiev; M Edwards; B A Duda; E Suchman; M Jacobs-Lorena; B J Beaty; J O Carlson
Journal: Insect Mol Biol Date: 2001-10 Impact factor: 3.585

2. Infection and pathogenicity of the mosquito densoviruses AeDNV, HeDNV, and APeDNV in Aedes aegypti mosquitoes (Diptera: Culicidae).

Authors: Jeremy P Ledermann; Erica L Suchman; William C Black; Jonathan O Carlson
Journal: J Econ Entomol Date: 2004-12 Impact factor: 2.381

Review 3. Densoviruses for control and genetic manipulation of mosquitoes.

Authors: Jonathan Carlson; Erica Suchman; Leonid Buchatsky
Journal: Adv Virus Res Date: 2006 Impact factor: 9.937

4. Exploiting the potential of vector control for disease prevention.

Authors: H Townson; M B Nathan; M Zaim; P Guillet; L Manga; R Bos; M Kindhauser
Journal: Bull World Health Organ Date: 2006-01-30 Impact factor: 9.408

5. Only the good die young: a novel paradigm for mosquito control.

Authors: Peter F Billingsley
Journal: Trends Parasitol Date: 2009-12-16

Review 6. How do animal DNA viruses get to the nucleus?

Authors: H Kasamatsu; A Nakanishi
Journal: Annu Rev Microbiol Date: 1998 Impact factor: 15.500

7. The global distribution of clinical episodes of Plasmodium falciparum malaria.

Authors: Robert W Snow; Carlos A Guerra; Abdisalan M Noor; Hla Y Myint; Simon I Hay
Journal: Nature Date: 2005-03-10 Impact factor: 49.962

Review 8. The global distribution and population at risk of malaria: past, present, and future.

Authors: Simon I Hay; Carlos A Guerra; Andrew J Tatem; Abdisalan M Noor; Robert W Snow
Journal: Lancet Infect Dis Date: 2004-06 Impact factor: 25.071

9. Wolbachia-induced mortality as a mechanism to modulate pathogen transmission by vector arthropods.

Authors: Jason L Rasgon; Linda M Styer; Thomas W Scott
Journal: J Med Entomol Date: 2003-03 Impact factor: 2.278

10. Statistical analysis of real-time PCR data.

Authors: Joshua S Yuan; Ann Reed; Feng Chen; C Neal Stewart
Journal: BMC Bioinformatics Date: 2006-02-22 Impact factor: 3.169

16 in total

Review 1. Densonucleosis viruses ('densoviruses') for mosquito and pathogen control.

Authors: Rebecca M Johnson; Jason L Rasgon
Journal: Curr Opin Insect Sci Date: 2018-05-24 Impact factor: 5.186

2. Sexual transmission of Anopheles gambiae densovirus (AgDNV) leads to disseminated infection in mated females.

Authors: Kristine L Werling; Rebecca M Johnson; Hillery C Metz; Jason L Rasgon
Journal: Parasit Vectors Date: 2022-06-20 Impact factor: 4.047

Review 3. Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes.

Authors: Joy Kean; Stephanie M Rainey; Melanie McFarlane; Claire L Donald; Esther Schnettler; Alain Kohl; Emilie Pondeville
Journal: Insects Date: 2015-03-23 Impact factor: 2.769

4. Anopheles gambiae densovirus (AgDNV) has negligible effects on adult survival and transcriptome of its mosquito host.

Authors: Xiaoxia Ren; Grant L Hughes; Guodong Niu; Yasutsugu Suzuki; Jason L Rasgon
Journal: PeerJ Date: 2014-09-18 Impact factor: 2.984

Review 5. Metagenomics, paratransgenesis and the Anopheles microbiome: a portrait of the geographical distribution of the anopheline microbiota based on a meta-analysis of reported taxa.

Authors: Luis Martínez Villegas; Paulo Filemon Paolucci Pimenta
Journal: Mem Inst Oswaldo Cruz Date: 2014-08 Impact factor: 2.743