BACKGROUND: There is a need for follow-up studies of the familial situation of multiple sclerosis (MS) patients. OBJECTIVES: To evaluate the probability of MS patients to remain in marriage or relationship with the same partner after onset of MS in comparison with the population. PATIENTS AND METHODS: All 2538 Danes with onset of MS 1980-1989, retrieved from the Danish MS-Registry, and 50,760 matched and randomly drawn control persons were included. Information on family status was retrieved from Statistics Denmark. Cox analyses were used with onset as starting point. RESULTS: Five years after onset, the cumulative probability of remaining in the same relationship was 86% in patients vs. 89% in controls. The probabilities continued to deviate, and at 24 years, the probability was 33% in patients vs. 53% in the control persons (p < 0.001). Among patients with young onset (< 36 years of age), those with no children had a higher risk of divorce than those having children less than 7 years (Hazard Ratio 1.51; p < 0.0001), and men had a higher risk of divorce than women (Hazard Ratio 1.33; p < 0.01). CONCLUSION: MS significantly affects the probability of remaining in the same relationship compared with the background population.
BACKGROUND: There is a need for follow-up studies of the familial situation of multiple sclerosis (MS) patients. OBJECTIVES: To evaluate the probability of MS patients to remain in marriage or relationship with the same partner after onset of MS in comparison with the population. PATIENTS AND METHODS: All 2538 Danes with onset of MS 1980-1989, retrieved from the Danish MS-Registry, and 50,760 matched and randomly drawn control persons were included. Information on family status was retrieved from Statistics Denmark. Cox analyses were used with onset as starting point. RESULTS: Five years after onset, the cumulative probability of remaining in the same relationship was 86% in patients vs. 89% in controls. The probabilities continued to deviate, and at 24 years, the probability was 33% in patients vs. 53% in the control persons (p < 0.001). Among patients with young onset (< 36 years of age), those with no children had a higher risk of divorce than those having children less than 7 years (Hazard Ratio 1.51; p < 0.0001), and men had a higher risk of divorce than women (Hazard Ratio 1.33; p < 0.01). CONCLUSION: MS significantly affects the probability of remaining in the same relationship compared with the background population.
Authors: Seth N Levin; Claire S Riley; Amar Dhand; Charles C White; Shruthi Venkatesh; Blake Boehm; Caren Nassif; Lauren Socia; Kaho Onomichi; Victoria M Leavitt; Libby Levine; Rock Heyman; Rebecca S Farber; Wendy S Vargas; Zongqi Xia; Philip L De Jager Journal: Neurology Date: 2020-08-07 Impact factor: 9.910
Authors: Archibald de Ceuninck van Capelle; Hanneke van der Meide; Frans J H Vosman; Leo H Visser Journal: PLoS One Date: 2017-08-24 Impact factor: 3.240
Authors: Abdullah Al-Asmi; Salim Al-Rawahi; Zahir Saif Al-Moqbali; Yahya Al-Farsi; Musthafa M Essa; May El-Bouri; Roopa P Koshy; Arunodaya R Gujjar; P C Jacob; Abeer Al-Hodar; Samir Al Adawi Journal: BMC Neurol Date: 2015-08-05 Impact factor: 2.474