| Literature DB >> 20483614 |
William D Schmitz1, Allison B Brenner, Joanne J Bronson, Jonathan L Ditta, Corrine R Griffin, Yu-Wen Li, Nicholas J Lodge, Thaddeus F Molski, Richard E Olson, Xiaoliang Zhuo, John E Macor.
Abstract
A series of 5-arylamino-1,2,4-triazin-6(1H)-ones was synthesized and evaluated as antagonists at the corticotropin releasing factor receptor. Formation of CYP-mediated oxidative reactive metabolites previously observed in a related N(3)-phenylpyrazinone structure was minimized by incorporation of the additional ring nitrogen found in the triazinones. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20483614 DOI： 10.1016/j.bmcl.2010.04.121
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823