| Literature DB >> 20483608 |
Nina Gommermann1, Peter Buehlmayer, Anette von Matt, Werner Breitenstein, Keiichi Masuya, Bernard Pirard, Pascal Furet, Sandra W Cowan-Jacob, Gisbert Weckbecker.
Abstract
A novel series of pyrazolo[1,5a]pyrimidines was optimized to target lymphocyte-specific kinase (Lck). An efficient synthetic route was developed and SAR studies toward activity and selectivity are described, leading to Lck inhibitors with enzymatic, cellular and in vivo potency. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20483608 DOI： 10.1016/j.bmcl.2010.04.112
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823