OBJECTIVES: To determine the persistence of newly recognized abnormal glucose metabolism in patients following acute ischemic stroke and delineate the possible predictive factors for this persistence. METHODS: A prospective observational study was performed. One hundred and twenty-three patients with acute first-ever ischemic stroke and no previous diagnosis of diabetes mellitus were enrolled consecutively. Information from baseline and laboratory tests was recorded. A standard oral glucose tolerance test was performed on the fourteenth day after onset and 3 months later, respectively. RESULTS: One hundred and seven patients completed the study. Thirty-nine patients (36.3%) were diagnosed as having newly recognized diabetes on the 14th day and 28 patients (26.1%) after 3 months. Among the patients diagnosed as having diabetes or impaired glucose tolerance during hospitalization, 68.6% remained to present with abnormal glucose metabolism 3 months later. Lower post-load plasma glucose on the fourteenth day was detected as a predictor for aggravated glucose metabolism after 3 months of onset. CONCLUSION: Majority of newly recognized abnormal glucose metabolism during hospitalization persisted 3 months later. Patients with lower post-load glucose level on the fourteenth day had higher risk for aggravated glucose metabolism 3 months later. Those with higher fasting glucose concentration on admission or higher 2 hour post-load plasma glucose on the fourteenth day had significantly high risk for diabetes after 3 months.
OBJECTIVES: To determine the persistence of newly recognized abnormal glucose metabolism in patients following acute ischemic stroke and delineate the possible predictive factors for this persistence. METHODS: A prospective observational study was performed. One hundred and twenty-three patients with acute first-ever ischemic stroke and no previous diagnosis of diabetes mellitus were enrolled consecutively. Information from baseline and laboratory tests was recorded. A standard oral glucose tolerance test was performed on the fourteenth day after onset and 3 months later, respectively. RESULTS: One hundred and seven patients completed the study. Thirty-nine patients (36.3%) were diagnosed as having newly recognized diabetes on the 14th day and 28 patients (26.1%) after 3 months. Among the patients diagnosed as having diabetes or impaired glucose tolerance during hospitalization, 68.6% remained to present with abnormal glucose metabolism 3 months later. Lower post-load plasma glucose on the fourteenth day was detected as a predictor for aggravated glucose metabolism after 3 months of onset. CONCLUSION: Majority of newly recognized abnormal glucose metabolism during hospitalization persisted 3 months later. Patients with lower post-load glucose level on the fourteenth day had higher risk for aggravated glucose metabolism 3 months later. Those with higher fasting glucose concentration on admission or higher 2 hour post-load plasma glucose on the fourteenth day had significantly high risk for diabetes after 3 months.
Authors: Feng Ning; Lei Zhang; Jacqueline M Dekker; Altan Onat; Coen D A Stehouwer; John S Yudkin; Tiina Laatikainen; Jaakko Tuomilehto; Kalevi Pyörälä; Qing Qiao Journal: Cardiovasc Diabetol Date: 2012-06-25 Impact factor: 9.951
Authors: David A McAllister; Katherine A Hughes; Nazir Lone; Nicholas L Mills; Naveed Sattar; John McKnight; Sarah H Wild Journal: PLoS Med Date: 2014-08-19 Impact factor: 11.069
Authors: Elizabeth Osei; Adrienne Zandbergen; Paul J A M Brouwers; Laus J M M Mulder; Peter Koudstaal; Hester Lingsma; Diederik W J Dippel; Heleen den Hertog Journal: BMJ Open Date: 2021-09-16 Impact factor: 2.692