QUESTION: Does 4 weeks of serial night casting followed by 4 weeks of stretching of the gastrocnemius and soleus improve ankle dorsiflexion range and other outcomes compared with no intervention in children and young adults with Charcot-Marie-Tooth disease? DESIGN: Randomised trial with concealed allocation, assessor blinding, and intention-to-treat analysis. PARTICIPANTS: 30 children and young adults with Charcot-Marie-Tooth disease and restricted ankle dorsiflexion range. INTERVENTION: The experimental group received 4 weeks of serial night casting followed by 4 weeks of weightbearing stretches. The control group received no intervention. OUTCOME MEASURES: Primary outcome was ankle dorsiflexion range; secondary outcomes included foot deformity, mobility, balance, falls, and self-reported activity limitations. Outcomes were measured at baseline, 4, and 8 weeks. RESULTS: By 4 weeks, serial night casting had increased ankle dorsiflexion range by a mean of 4 deg (95% CI 2 to 6) more in the experimental group than the control group. After a further 4 weeks of weightbearing stretches, the experimental group still had a mean of 3 deg (95% CI 0 to 5) more ankle dorsiflexion range than the control group. Other than reduced time to walk 10 metres at self-selected pace favouring night casting at 4 weeks, outcomes did not differ between groups at any time point. Two minor adverse events were reported in the experimental group. CONCLUSION: 4 weeks of serial night casting increased ankle dorsiflexion range compared with no intervention, but at 8 weeks there was no significant difference between groups.
RCT Entities:
QUESTION: Does 4 weeks of serial night casting followed by 4 weeks of stretching of the gastrocnemius and soleus improve ankle dorsiflexion range and other outcomes compared with no intervention in children and young adults with Charcot-Marie-Tooth disease? DESIGN: Randomised trial with concealed allocation, assessor blinding, and intention-to-treat analysis. PARTICIPANTS: 30 children and young adults with Charcot-Marie-Tooth disease and restricted ankle dorsiflexion range. INTERVENTION: The experimental group received 4 weeks of serial night casting followed by 4 weeks of weightbearing stretches. The control group received no intervention. OUTCOME MEASURES: Primary outcome was ankle dorsiflexion range; secondary outcomes included foot deformity, mobility, balance, falls, and self-reported activity limitations. Outcomes were measured at baseline, 4, and 8 weeks. RESULTS: By 4 weeks, serial night casting had increased ankle dorsiflexion range by a mean of 4 deg (95% CI 2 to 6) more in the experimental group than the control group. After a further 4 weeks of weightbearing stretches, the experimental group still had a mean of 3 deg (95% CI 0 to 5) more ankle dorsiflexion range than the control group. Other than reduced time to walk 10 metres at self-selected pace favouring night casting at 4 weeks, outcomes did not differ between groups at any time point. Two minor adverse events were reported in the experimental group. CONCLUSION: 4 weeks of serial night casting increased ankle dorsiflexion range compared with no intervention, but at 8 weeks there was no significant difference between groups.
Authors: Melissa R Mandarakas; Manoj P Menezes; Kristy J Rose; Rosemary Shy; Kate Eichinger; Maria Foscan; Timothy Estilow; Rachel Kennedy; Karen Herbert; Paula Bray; Kathryn Refshauge; Monique M Ryan; Eppie M Yiu; Michelle Farrar; Hugo Sampaio; Isabella Moroni; Emanuela Pagliano; Davide Pareyson; Sabrina W Yum; David N Herrmann; Gyula Acsadi; Michael E Shy; Joshua Burns; Oranee Sanmaneechai Journal: Brain Date: 2018-12-01 Impact factor: 13.501
Authors: Allan M Glanzman; Jean M Flickinger; Kripa H Dholakia; Carsten G Bönnemann; Richard S Finkel Journal: Pediatr Phys Ther Date: 2011 Impact factor: 3.049
Authors: Lisa A Harvey; Owen M Katalinic; Robert D Herbert; Anne M Moseley; Natasha A Lannin; Karl Schurr Journal: Cochrane Database Syst Rev Date: 2017-01-09
Authors: Cyntia Rogean de Jesus Alves de Baptista; Adriana Nascimento-Elias; Tenysson Will Lemos; Beatriz Garcia; Paula Domingues Calori; Ana Claudia Mattiello-Sverzut Journal: PLoS One Date: 2018-10-10 Impact factor: 3.240