BACKGROUND: Acute kidney injury (AKI) following cardiac surgery with cardiopulmonary bypass (CPB) causes increased morbidity and mortality. OBJECTIVE: To evaluate the plasma profile of biomarkers potentially involved in AKI development following CPB. METHODS: In a nested case-control study, plasma levels of 27 biomarkers in 11 AKI cases were compared with 25 controls. RESULTS: Pre-CPB, plasma levels of epidermal growth factor and macrophage inflammatory protein-1beta, 2 h following CPB, soluble vascular cell adhesion molecule-1 (sVCAM-1), fractalkine and macrophage inflammatory protein-1alpha, and at later time points, sVCAM-1 and interleukin-6 were associated with AKI. CONCLUSION: Biomarkers associated with AKI following CPB may merit further study.
BACKGROUND:Acute kidney injury (AKI) following cardiac surgery with cardiopulmonary bypass (CPB) causes increased morbidity and mortality. OBJECTIVE: To evaluate the plasma profile of biomarkers potentially involved in AKI development following CPB. METHODS: In a nested case-control study, plasma levels of 27 biomarkers in 11 AKI cases were compared with 25 controls. RESULTS: Pre-CPB, plasma levels of epidermal growth factor and macrophage inflammatory protein-1beta, 2 h following CPB, soluble vascular cell adhesion molecule-1 (sVCAM-1), fractalkine and macrophage inflammatory protein-1alpha, and at later time points, sVCAM-1 and interleukin-6 were associated with AKI. CONCLUSION: Biomarkers associated with AKI following CPB may merit further study.
Authors: G Paret; T Prince; N Keller; O Dagan; Y Sasson; A Barzilai; D Guthmann; Z Barzilay Journal: J Cardiothorac Vasc Anesth Date: 2000-08 Impact factor: 2.628
Authors: G Görlach; J Sroka; M Heidt; I Knez; A Sablotzki; M Schönburg; H Akintürk; P Roth; G Wozniak; P R Vogt Journal: Thorac Cardiovasc Surg Date: 2003-06 Impact factor: 1.827
Authors: John S K Kauwe; Matthew H Bailey; Perry G Ridge; Rachel Perry; Mark E Wadsworth; Kaitlyn L Hoyt; Lyndsay A Staley; Celeste M Karch; Oscar Harari; Carlos Cruchaga; Benjamin J Ainscough; Kelly Bales; Eve H Pickering; Sarah Bertelsen; Anne M Fagan; David M Holtzman; John C Morris; Alison M Goate Journal: PLoS Genet Date: 2014-10-23 Impact factor: 5.917
Authors: Gunnar Schley; Carmen Köberle; Ekaterina Manuilova; Sandra Rutz; Christian Forster; Michael Weyand; Ivan Formentini; Rosemarie Kientsch-Engel; Kai-Uwe Eckardt; Carsten Willam Journal: PLoS One Date: 2015-12-15 Impact factor: 3.240