OBJECTIVE: To compare the performance of prototype Access® sVEGF R1 and PlGF automated immunoassays from Beckman Coulter to the Quantikine® microplate ELISA assays by R&D Systems. METHODS: Samples obtained from pregnant women, non-pregnant women and men were assayed according to manufacturers' instructions. RESULTS: Compared to the Quantikine assays, the Access assays demonstrated improved precision, increased sensitivity, broader dynamic ranges, and reduced analysis time. The Access assays were found to be specific for free sVEGF R1 and free PlGF. CONCLUSION: There was good correlation between the Access and Quantikine assays. Superior performance by Access assays may have important prenatal diagnostic implications.
OBJECTIVE: To compare the performance of prototype Access® sVEGF R1 and PlGF automated immunoassays from Beckman Coulter to the Quantikine® microplate ELISA assays by R&D Systems. METHODS: Samples obtained from pregnant women, non-pregnant women and men were assayed according to manufacturers' instructions. RESULTS: Compared to the Quantikine assays, the Access assays demonstrated improved precision, increased sensitivity, broader dynamic ranges, and reduced analysis time. The Access assays were found to be specific for free sVEGF R1 and free PlGF. CONCLUSION: There was good correlation between the Access and Quantikine assays. Superior performance by Access assays may have important prenatal diagnostic implications.
Authors: Ravi Thadhani; Walter P Mutter; Myles Wolf; Richard J Levine; Robert N Taylor; Vikas P Sukhatme; Jeffrey Ecker; S Ananth Karumanchi Journal: J Clin Endocrinol Metab Date: 2004-02 Impact factor: 5.958
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