Literature DB >> 20482087

Microdynamics and criticality of adaptive regulatory networks.

Ben D MacArthur1, Rubén J Sánchez-García, Avi Ma'ayan.   

Abstract

We present a model of adaptive regulatory networks consisting of a simple biologically motivated rewiring procedure coupled to an elementary stability criterion. The resulting networks exhibit a characteristic stationary heavy-tailed degree distribution, show complex structural microdynamics, and self-organize to a dynamically critical state. We show analytically that the observed criticality results from the formation and breaking of transient feedback loops during the adaptive process.

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Year:  2010        PMID: 20482087      PMCID: PMC2925242          DOI: 10.1103/PhysRevLett.104.168701

Source DB:  PubMed          Journal:  Phys Rev Lett        ISSN: 0031-9007            Impact factor:   9.161


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