| Literature DB >> 20481453 |
Daniel R Fandrick1, Keith R Fandrick, Jonathan T Reeves, Zhulin Tan, Wenjun Tang, Andrew G Capacci, Sonia Rodriguez, Jinhua J Song, Heewon Lee, Nathan K Yee, Chris H Senanayake.
Abstract
The highly enantio- and regioselective copper catalyzed asymmetric propargylation of aldehydes with a propargyl borolane reagent is reported. The methodology demonstrated broad functional group tolerance and provided high enantioselectivities for aliphatic, vinyl, and aryl aldehydes. The utility of the TMS homopropargylic alcohols was demonstrated by the facile conversion to a chiral dihydropyranone.Entities:
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Year: 2010 PMID： 20481453 DOI： 10.1021/ja103312x
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419