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Literature DB >> 20480243

The emerging role of adipokines in osteoarthritis: a narrative review.

Abstract

Osteoarthritis (OA) is a most common multifactorial degenerative joint disease in elderly individuals. OA is affecting severely the quality of life of patients, while the causes of OA are not completely understood. Age, obesity, the female sex, and previous injury are considered as significant risk factors. Recently, increased levels of adipokines which are mainly produced by adipocytes have been detected in patients with osteoarthritis. Moreover, studies on different adipokines all reveal that they have played proinflammatory and catabolic/anabolic roles during the pathophysiology of OA. In the present review, we summarize current data on the effect of the adipose tissue-derived hormones leptin, adiponectin, resistin and visfatin on initiation and progression of OA.

Entities: Disease Gene Species

Mesh：

Substances：

Year: 2010 PMID： 20480243 DOI： 10.1007/s11033-010-0179-y

Source DB: PubMed Journal: Mol Biol Rep ISSN： 0301-4851 Impact factor: 2.316

37 in total

1. Adiponectin and JNK: metabolic/inflammatory pathways affecting gastrointestinal carcinogenesis.

Authors: Herbert Tilg; Arthur Kaser
Journal: Gut Date: 2009-12 Impact factor: 23.059

2. Evidence for a protective role for adiponectin in osteoarthritis.

Authors: Tsu-Hsin Chen; Linda Chen; Ming-Shium Hsieh; Chih-Peng Chang; Der-Tsay Chou; Shu-Huei Tsai
Journal: Biochim Biophys Acta Date: 2006-07-01

3. Regulation of pre-B cell colony-enhancing factor by STAT-3-dependent interleukin-6 trans-signaling: implications in the pathogenesis of rheumatoid arthritis.

Authors: Mari A Nowell; Peter J Richards; Ceri A Fielding; Simona Ognjanovic; Nick Topley; Anwen S Williams; Gillian Bryant-Greenwood; Simon A Jones
Journal: Arthritis Rheum Date: 2006-07

4. Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans.

Authors: D B Savage; C P Sewter; E S Klenk; D G Segal; A Vidal-Puig; R V Considine; S O'Rahilly
Journal: Diabetes Date: 2001-10 Impact factor: 9.461

5. Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway.

Authors: Nirupama Silswal; Anil K Singh; Battu Aruna; Sangita Mukhopadhyay; Sudip Ghosh; Nasreen Z Ehtesham
Journal: Biochem Biophys Res Commun Date: 2005-09-09 Impact factor: 3.575

6. Pre-B cell colony-enhancing factor/visfatin, a new marker of inflammation in rheumatoid arthritis with proinflammatory and matrix-degrading activities.

Authors: Fabia Brentano; Olivier Schorr; Caroline Ospelt; Joanna Stanczyk; Renate E Gay; Steffen Gay; Diego Kyburz
Journal: Arthritis Rheum Date: 2007-09

7. Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme.

Authors: Javier R Revollo; Antje Körner; Kathryn F Mills; Akiko Satoh; Tao Wang; Antje Garten; Biplab Dasgupta; Yo Sasaki; Cynthia Wolberger; R Reid Townsend; Jeffrey Milbrandt; Wieland Kiess; Shin-Ichiro Imai
Journal: Cell Metab Date: 2007-11 Impact factor: 27.287

8. Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway.

Authors: Chih-Hsin Tang; Yung-Cheng Chiu; Tzu-Wei Tan; Rong-Sen Yang; Wen-Mei Fu
Journal: J Immunol Date: 2007-10-15 Impact factor: 5.422

9. A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes.

Authors: R Lago; R Gomez; M Otero; F Lago; R Gallego; C Dieguez; J J Gomez-Reino; O Gualillo
Journal: Osteoarthritis Cartilage Date: 2008-02-07 Impact factor: 6.576

10. Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than proinflammatory mediators.

Authors: Hyun-Mi Choi; Yeon-Ah Lee; Sang-Hoon Lee; Seung-Jae Hong; Dae-Hyun Hahm; Sang-Yun Choi; Hyung-In Yang; Myung Chul Yoo; Kyoung Soo Kim
Journal: Arthritis Res Ther Date: 2009-11-02 Impact factor: 5.156

32 in total

Review 1. Roles of leptin in bone metabolism and bone diseases.

Authors: Xu Xu Chen; Tianfu Yang
Journal: J Bone Miner Metab Date: 2015-03-18 Impact factor: 2.626

2. Circulating levels of adiponectin, resistin, and visfatin after mud-bath therapy in patients with bilateral knee osteoarthritis.

Authors: Antonella Fioravanti; Chiara Giannitti; Sara Cheleschi; Antonella Simpatico; Nicola Antonio Pascarelli; Mauro Galeazzi
Journal: Int J Biometeorol Date: 2015-03-07 Impact factor: 3.787

3. Molecular cloning, tissue distribution and ontogenetic expression of Xiang pig chemerin and its involvement in regulating energy metabolism through Akt and ERK1/2 signaling pathways.

Authors: Huansheng Yang; Fengna Li; Xiangfeng Kong; Xiaoxue Yuan; Guoqi Lian; Meimei Geng; Tiejun Li; Jingdong Yin; Yulong Yin
Journal: Mol Biol Rep Date: 2011-06-05 Impact factor: 2.316

4. Serum adipokines, adipose tissue measurements and metabolic parameters in patients with advanced radiographic knee osteoarthritis.

Authors: Eric Toussirot; Fabrice Michel; Matthieu Béreau; Barbara Dehecq; Béatrice Gaugler; Daniel Wendling; Emilie Grandclément; Philippe Saas; Gilles Dumoulin
Journal: Clin Rheumatol Date: 2017-08-22 Impact factor: 2.980