Literature DB >> 20480240

Wafer-scale fabrication of penetrating neural microelectrode arrays.

Rajmohan Bhandari1, Sandeep Negi, Florian Solzbacher.   

Abstract

The success achieved with implantable neural interfaces has motivated the development of novel architectures of electrode arrays and the improvement of device performance. The Utah electrode array (UEA) is one example of such a device. The unique architecture of the UEA enables single-unit recording with high spatial and temporal resolution. Although the UEA has been commercialized and been used extensively in neuroscience and clinical research, the current processes used to fabricate UEA's impose limitations in the tolerances of the electrode array geometry. Further, existing fabrication costs have led to the need to develop less costly but higher precision batch fabrication processes. This paper presents a wafer-scale fabrication method for the UEA that enables both lower costs and faster production. More importantly, the wafer-scale fabrication significantly improves the quality and tolerances of the electrode array and allow better controllability in the electrode geometry. A comparison between the geometrical and electrical characteristics of the wafer-scale and conventional array-scale processed UEA's is presented.

Mesh:

Year:  2010        PMID: 20480240     DOI: 10.1007/s10544-010-9434-1

Source DB:  PubMed          Journal:  Biomed Microdevices        ISSN: 1387-2176            Impact factor:   2.838


  13 in total

1.  In Vitro/Ex Vivo Investigation of Modified Utah Electrode Array to Selectively Sense and Pace the Sub-Surface Cardiac His Bundle.

Authors:  Ankur R Shah; Muhammad S Khan; Annie M Hirahara; Matthias Lange; Ravi Ranjan; Derek J Dosdall
Journal:  ACS Biomater Sci Eng       Date:  2020-05-07

2.  Syringe-injectable mesh electronics integrate seamlessly with minimal chronic immune response in the brain.

Authors:  Tao Zhou; Guosong Hong; Tian-Ming Fu; Xiao Yang; Thomas G Schuhmann; Robert D Viveros; Charles M Lieber
Journal:  Proc Natl Acad Sci U S A       Date:  2017-05-22       Impact factor: 11.205

3.  Biological Interfaces, Modulation, and Sensing with Inorganic Nano-Bioelectronic Materials.

Authors:  Erik N Schaumann; Bozhi Tian
Journal:  Small Methods       Date:  2020-03-08

4.  A Wafer-Scale Etching Technique for High Aspect Ratio Implantable MEMS Structures.

Authors:  R Bhandari; S Negi; L Rieth; F Solzbacher
Journal:  Sens Actuators A Phys       Date:  2010-07-01       Impact factor: 3.407

5.  Microelectrode arrays fabricated using a novel hybrid microfabrication method.

Authors:  Mark W Merlo; Russell L Snyder; John C Middlebrooks; Mark Bachman
Journal:  Biomed Microdevices       Date:  2012-02       Impact factor: 2.838

Review 6.  Progress towards biocompatible intracortical microelectrodes for neural interfacing applications.

Authors:  Mehdi Jorfi; John L Skousen; Christoph Weder; Jeffrey R Capadona
Journal:  J Neural Eng       Date:  2014-12-02       Impact factor: 5.379

7.  Single 5 μm diameter needle electrode block modules for unit recordings in vivo.

Authors:  H Sawahata; S Yamagiwa; A Moriya; T Dong; H Oi; Y Ando; R Numano; M Ishida; K Koida; T Kawano
Journal:  Sci Rep       Date:  2016-10-25       Impact factor: 4.379

8.  In vivo characterization of the electrophysiological and astrocytic responses to a silicon neuroprobe implanted in the mouse neocortex.

Authors:  Katrien Mols; Silke Musa; Bart Nuttin; Liesbet Lagae; Vincent Bonin
Journal:  Sci Rep       Date:  2017-11-15       Impact factor: 4.379

Review 9.  Neural Interfaces for Intracortical Recording: Requirements, Fabrication Methods, and Characteristics.

Authors:  Katarzyna M Szostak; Laszlo Grand; Timothy G Constandinou
Journal:  Front Neurosci       Date:  2017-12-07       Impact factor: 4.677

10.  Utah optrode array customization using stereotactic brain atlases and 3-D CAD modeling for optogenetic neocortical interrogation in small rodents and nonhuman primates.

Authors:  Ronald W Boutte; Sam Merlin; Guy Yona; Brandon Griffiths; Alessandra Angelucci; Itamar Kahn; Shy Shoham; Steve Blair
Journal:  Neurophotonics       Date:  2017-07-12       Impact factor: 3.593

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