Literature DB >> 204797

Effect of the Fv-1 locus in vivo: host range pseudotypes of murine sarcoma virus.

J A Otten, F E Myer, R W Tennant, A Brown.   

Abstract

Fv-1-specific host-range pseudotypes of murine sarcoma virus (MuSV) were developed by rescue from nonproducer cells with N- or B-tropic leukemia viruses. The MuSV(B) and MuSV(N) pseudotype viruses were tested in vitro and were restricted specifically by the Fv-1 gene locus. When the pseudo-type viruses were tested in vivo in mice of specific Fv-1 geno-types, tumor induction was completely restricted in nonpermissive animals, including athymic nude mice, whereas tumors grew progressively in permissive animals. All tumors regressed in adult heterozygous mice, but not in adult athymic nude mice.

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Year:  1978        PMID： 204797     DOI： 10.1093/jnci/60.4.875

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   13.506


  7 in total

1.  Transfer of Fv-1 locus-specific resistance to murine N-tropic and B-tropic retroviruses by cytoplasmic RNA.

Authors:  W K Yang; R W Tennant; R J Rascati; J A Otten; B Schluter; J O Kiggans; F E Myer; A Brown
Journal:  J Virol       Date:  1978-08       Impact factor: 5.103

2.  Analysis of proteins of mouse sarcoma pseudotype viruses: type-specific radioimmunoassay for ecotropic virus p30's.

Authors:  S J Kennel; R W Tennant
Journal:  J Virol       Date:  1979-06       Impact factor: 5.103

3.  Adaptation of chimeric retroviruses in vitro and in vivo: isolation of avian retroviral vectors with extended host range.

Authors:  E V Barsov; W S Payne; S H Hughes
Journal:  J Virol       Date:  2001-06       Impact factor: 5.103

4.  Host restriction of Friend leukemia virus: gag proteins of host range variants.

Authors:  S Duttagupta; R Soeiro
Journal:  Proc Natl Acad Sci U S A       Date:  1981-04       Impact factor: 11.205

5.  Effect of Fv-1 gene product on synthesis of linear and supercoiled viral DNA in cells infected with murine leukemia virus.

Authors:  P Jolicoeur; E Rassart
Journal:  J Virol       Date:  1980-01       Impact factor: 5.103

6.  Reversal of Fv-1 host range by in vitro restriction endonuclease fragment exchange between molecular clones of N-tropic and B-tropic murine leukemia virus genomes.

Authors:  L R Boone; F E Myer; D M Yang; C Y Ou; C K Koh; L E Roberson; R W Tennant; W K Yang
Journal:  J Virol       Date:  1983-10       Impact factor: 5.103

7.  Physical mapping of the Fv-1 tropism host range determinant of BALB/c murine leukemia viruses.

Authors:  L DesGroseillers; P Jolicoeur
Journal:  J Virol       Date:  1983-12       Impact factor: 5.103
  7 in total

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