| Literature DB >> 20479199 |
Juan Luis Rodriguez-Tudela1, Alicia Gomez-Lopez, Maiken C Arendrup, Guillermo Garcia-Effron, David S Perlin, Cornelia Lass-Flörl, Manuel Cuenca-Estrella.
Abstract
According to the product insert for Cancidas (caspofungin acetate), the drug must not be diluted in solutions containing glucose as this decreases caspofungin stability. The aim of this study was to compare caspofungin MICs for a collection of yeasts by means of EUCAST method EDef7.1 but using two different concentrations of glucose: 2% versus 0.2%. MICs were identical or within one 2-fold dilution for 93 out of 95 strains (97.9%), showing that glucose does not interfere with susceptibility.Entities:
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Year: 2010 PMID: 20479199 PMCID: PMC2897297 DOI: 10.1128/AAC.00597-10
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191