OBJECTIVE: The goal was to examine the association between urinary concentrations of dialkyl phosphate metabolites of organophosphates and attention-deficit/hyperactivity disorder (ADHD) in children 8 to 15 years of age. METHODS: Cross-sectional data from the National Health and Nutrition Examination Survey (2000-2004) were available for 1139 children, who were representative of the general US population. A structured interview with a parent was used to ascertain ADHD diagnostic status, on the basis of slightly modified criteria from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. RESULTS: One hundred nineteen children met the diagnostic criteria for ADHD. Children with higher urinary dialkyl phosphate concentrations, especially dimethyl alkylphosphate (DMAP) concentrations, were more likely to be diagnosed as having ADHD. A 10-fold increase in DMAP concentration was associated with an odds ratio of 1.55 (95% confidence interval: 1.14-2.10), with adjustment for gender, age, race/ethnicity, poverty/income ratio, fasting duration, and urinary creatinine concentration. For the most-commonly detected DMAP metabolite, dimethyl thiophosphate, children with levels higher than the median of detectable concentrations had twice the odds of ADHD (adjusted odds ratio: 1.93 [95% confidence interval: 1.23-3.02]), compared with children with undetectable levels. CONCLUSIONS: These findings support the hypothesis that organophosphate exposure, at levels common among US children, may contribute to ADHD prevalence. Prospective studies are needed to establish whether this association is causal.
OBJECTIVE: The goal was to examine the association between urinary concentrations of dialkyl phosphate metabolites of organophosphates and attention-deficit/hyperactivity disorder (ADHD) in children 8 to 15 years of age. METHODS: Cross-sectional data from the National Health and Nutrition Examination Survey (2000-2004) were available for 1139 children, who were representative of the general US population. A structured interview with a parent was used to ascertain ADHD diagnostic status, on the basis of slightly modified criteria from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. RESULTS: One hundred nineteen children met the diagnostic criteria for ADHD. Children with higher urinary dialkyl phosphate concentrations, especially dimethyl alkylphosphate (DMAP) concentrations, were more likely to be diagnosed as having ADHD. A 10-fold increase in DMAP concentration was associated with an odds ratio of 1.55 (95% confidence interval: 1.14-2.10), with adjustment for gender, age, race/ethnicity, poverty/income ratio, fasting duration, and urinary creatinine concentration. For the most-commonly detected DMAP metabolite, dimethyl thiophosphate, children with levels higher than the median of detectable concentrations had twice the odds of ADHD (adjusted odds ratio: 1.93 [95% confidence interval: 1.23-3.02]), compared with children with undetectable levels. CONCLUSIONS: These findings support the hypothesis that organophosphate exposure, at levels common among US children, may contribute to ADHD prevalence. Prospective studies are needed to establish whether this association is causal.
Authors: M Bravo; J Ribera; M Rubio-Stipec; G Canino; P Shrout; R Ramírez; L Fábregas; L Chavez; M Alegría; J J Bauermeister; A Martínez Taboas Journal: J Abnorm Child Psychol Date: 2001-10
Authors: Roberto Bravo; Lisa M Caltabiano; Gayanga Weerasekera; Ralph D Whitehead; Carolina Fernandez; Larry L Needham; Asa Bradman; Dana B Barr Journal: J Expo Anal Environ Epidemiol Date: 2004-05
Authors: Glorisa Canino; Patrick E Shrout; Maritza Rubio-Stipec; Hector R Bird; Milagros Bravo; Rafael Ramirez; Ligia Chavez; Margarita Alegria; José J Bauermeister; Ann Hohmann; Julio Ribera; Pedro Garcia; Alfonso Martinez-Taboas Journal: Arch Gen Psychiatry Date: 2004-01
Authors: E A Cohen Hubal; L S Sheldon; J M Burke; T R McCurdy; M R Berry; M L Rigas; V G Zartarian; N C Freeman Journal: Environ Health Perspect Date: 2000-06 Impact factor: 9.031
Authors: Dana B Barr; Roberto Bravo; Gayanga Weerasekera; Lisa M Caltabiano; Ralph D Whitehead; Anders O Olsson; Samuel P Caudill; Susan E Schober; James L Pirkle; Eric J Sampson; Richard J Jackson; Larry L Needham Journal: Environ Health Perspect Date: 2004-02 Impact factor: 9.031
Authors: Joe M Braun; Roberto Lucchini; David C Bellinger; Elaine Hoffman; Marco Nazzaro; Donald R Smith; Robert O Wright Journal: Neurotoxicology Date: 2012-07-06 Impact factor: 4.294
Authors: Diane S Rohlman; Ahmed A Ismail; Gaafar Abdel Rasoul; Matthew R Bonner; Olfat Hendy; Kristin Mara; Kai Wang; James R Olson Journal: Cortex Date: 2015-10-20 Impact factor: 4.027
Authors: Daniel Medina-Cleghorn; Ann Heslin; Patrick J Morris; Melinda M Mulvihill; Daniel K Nomura Journal: ACS Chem Biol Date: 2013-11-20 Impact factor: 5.100
Authors: María Teresa Muñoz-Quezada; Boris A Lucero; Dana B Barr; Kyle Steenland; Karen Levy; P Barry Ryan; Veronica Iglesias; Sergio Alvarado; Carlos Concha; Evelyn Rojas; Catalina Vega Journal: Neurotoxicology Date: 2013-10-09 Impact factor: 4.294
Authors: Ryan C Lewis; David E Cantonwine; Liza V Anzalota Del Toro; Antonia M Calafat; Liza Valentin-Blasini; Mark D Davis; M Angela Montesano; Akram N Alshawabkeh; José F Cordero; John D Meeker Journal: Sci Total Environ Date: 2015-01-27 Impact factor: 7.963
Authors: Jason R Richardson; Michele M Taylor; Stuart L Shalat; Thomas S Guillot; W Michael Caudle; Muhammad M Hossain; Tiffany A Mathews; Sara R Jones; Deborah A Cory-Slechta; Gary W Miller Journal: FASEB J Date: 2015-01-28 Impact factor: 5.191