| Literature DB >> 20478531 |
Hongwu Zheng1, Haoqiang Ying, Ruprecht Wiedemeyer, Haiyan Yan, Steven N Quayle, Elena V Ivanova, Ji-Hye Paik, Hailei Zhang, Yonghong Xiao, Samuel R Perry, Jian Hu, Anant Vinjamoori, Boyi Gan, Ergun Sahin, Milan G Chheda, Cameron Brennan, Y Alan Wang, William C Hahn, Lynda Chin, Ronald A DePinho.
Abstract
A hallmark feature of glioblastoma is its strong self-renewal potential and immature differentiation state, which contributes to its plasticity and therapeutic resistance. Here, integrated genomic and biological analyses identified PLAGL2 as a potent protooncogene targeted for amplification/gain in malignant gliomas. Enhanced PLAGL2 expression strongly suppresses neural stem cell (NSC) and glioma-initiating cell differentiation while promoting their self-renewal capacity upon differentiation induction. Transcriptome analysis revealed that these differentiation-suppressive activities are attributable in part to PLAGL2 modulation of Wnt/beta-catenin signaling. Inhibition of Wnt signaling partially restores PLAGL2-expressing NSC differentiation capacity. The identification of PLAGL2 as a glioma oncogene highlights the importance of a growing class of cancer genes functioning to impart stem cell-like characteristics in malignant cells. (c) 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20478531 PMCID： PMC2900858 DOI： 10.1016/j.ccr.2010.03.020
Source DB: PubMed Journal: Cancer Cell ISSN： 1535-6108 Impact factor: 31.743