Literature DB >> 20478524

Unveiling the secrets of the ancestral PI3 kinase Vps34.

Paul Workman1, Rob L M van Montfort.   

Abstract

Vps34 is the primordial member of the PI3 kinase family involved in vesicular trafficking, nutrient signaling, and autophagy. A report in Science unveils the Vps34 structure, providing new insights into the catalytic mechanism, explaining why Vsp34 is so difficult to inhibit, and facilitating design of chemical tools and potential drugs. (c) 2010 Elsevier Inc. All rights reserved.

Entities:  

Year:  2010        PMID： 20478524     DOI： 10.1016/j.ccr.2010.04.016

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  7 in total

1.  MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature.

Authors:  Nathalie Gaspar; Lynley Marshall; Lara Perryman; Dorine A Bax; Suzanne E Little; Marta Viana-Pereira; Swee Y Sharp; Gilles Vassal; Andrew D J Pearson; Rui M Reis; Darren Hargrave; Paul Workman; Chris Jones
Journal:  Cancer Res       Date:  2010-10-08       Impact factor: 12.701

Review 2.  Progress in the preclinical discovery and clinical development of class I and dual class I/IV phosphoinositide 3-kinase (PI3K) inhibitors.

Authors:  S J Shuttleworth; F A Silva; A R L Cecil; C D Tomassi; T J Hill; F I Raynaud; P A Clarke; P Workman
Journal:  Curr Med Chem       Date:  2011       Impact factor: 4.530

Review 3.  Regulation of the Tumor-Suppressor Function of the Class III Phosphatidylinositol 3-Kinase Complex by Ubiquitin and SUMO.

Authors:  Christina Reidick; Fouzi El Magraoui; Helmut E Meyer; Harald Stenmark; Harald W Platta
Journal:  Cancers (Basel)       Date:  2014-12-23       Impact factor: 6.639

Review 4.  Regulation of the Tumor-Suppressor BECLIN 1 by Distinct Ubiquitination Cascades.

Authors:  Fahd Boutouja; Rebecca Brinkmeier; Thomas Mastalski; Fouzi El Magraoui; Harald W Platta
Journal:  Int J Mol Sci       Date:  2017-11-27       Impact factor: 5.923

Review 5.  HSF-1: Guardian of the Proteome Through Integration of Longevity Signals to the Proteostatic Network.

Authors:  Maria I Lazaro-Pena; Zachary C Ward; Sifan Yang; Alexandra Strohm; Alyssa K Merrill; Celia A Soto; Andrew V Samuelson
Journal:  Front Aging       Date:  2022-07-08

6.  Gene expression correlation for cancer diagnosis: a pilot study.

Authors:  Binbing Ling; Lifeng Chen; Qiang Liu; Jian Yang
Journal:  Biomed Res Int       Date:  2014-04-09       Impact factor: 3.411

7.  PIK3C3 regulates the expansion of liver CSCs and PIK3C3 inhibition counteracts liver cancer stem cell activity induced by PI3K inhibitor.

Authors:  Fengchao Liu; Xiaoling Wu; Yanzhi Qian; Xin Jiang; Yiying Wang; Jian Gao
Journal:  Cell Death Dis       Date:  2020-06-08       Impact factor: 8.469
  7 in total

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