A multipronged approach to the identification and study of an important oncogene in GBM.

In this issue of Cancer Cell, Zheng et al. provide strong evidence that PLAGL2 serves as an oncogene in GBM. They demonstrate that PLAGL2 inhibits differentiation and promotes a persistent, self-renewing state, at least in part because of activation of Wnt signaling. (c) 2010 Elsevier Inc. All rights reserved.