| Literature DB >> 20478334 |
H Ehrlich1, E Steck, M Ilan, M Maldonado, G Muricy, G Bavestrello, Z Kljajic, J L Carballo, S Schiaparelli, A Ereskovsky, P Schupp, R Born, H Worch, V V Bazhenov, D Kurek, V Varlamov, D Vyalikh, K Kummer, V V Sivkov, S L Molodtsov, H Meissner, G Richter, S Hunoldt, M Kammer, S Paasch, V Krasokhin, G Patzke, E Brunner, W Richter.
Abstract
In order to evaluate the biomedical potential of three-dimensional chitinous scaffolds of poriferan origin, chondrocyte culturing experiments were performed. It was shown for the first time that freshly isolated chondrocytes attached well to the chitin scaffold and synthesized an extracellular matrix similar to that found in other cartilage tissue engineering constructs. Chitin scaffolds also supported deposition of a proteoglycan-rich extracellular matrix of chondrocytes seeded bioconstructs in an in vivo environment. We suggest that chitin sponge scaffolds, apart from the demonstrated biomedical applications, are highly optimized structures for use as filtering systems, templates for biomineralization as well as metallization in order to produce catalysts. Copyright 2010 Elsevier B.V. All rights reserved.Entities:
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Year: 2010 PMID： 20478334 DOI： 10.1016/j.ijbiomac.2010.05.009
Source DB: PubMed Journal: Int J Biol Macromol ISSN： 0141-8130 Impact factor: 6.953