Chemokines, chemokine receptors and CD4+CD25+ regulatory T cells.

The fields of regulatory T (Treg) cells and chemokines/chemokine receptors have progressed rapidly in the last few years. Treg cells, especially CD4(+)CD25(+) Treg cells, play a critical role in maintaining self-tolerance and immune homeostasis. Chemokines and chemokine receptors are crucial for lymphoid development, homing and immunological regulation. This review will discuss the biological effects of chemokines and chemokine receptors on regulating the migration and development of CD4(+)CD25(+) Treg cells, and the potential clinical implications of these findings when considering chemokine receptors as therapeutic targets.