Megan Spencer-Smith1, Vicki Anderson. 1. Critical Care and Neurosciences, Murdoch Childrens Research Institute, Royal Children's Hospital, FlemingtonRoad, Parkville, VIC 3054, Australia. megan.spencer-smith@mcri.edu.au
Abstract
BACKGROUND: While many children with brain conditions present with cognitive, behavioural, emotional, academic and social impairments, other children recover with seemingly few impairments. Animal studies and preliminary child studies have identified timing of brain lesion as a key predictor in determining functional outcome following early brain lesions. REVIEW: This research suggests that knowledge of healthy developmental processes in brain structure and function is essential for better understanding functional recovery and outcome in children with brain lesions. This review paper aims to equip researchers with current knowledge of key principles of developmental processes in brain structure and function. Timetables for development of the prefrontal cortex (PFC), a brain region particularly vulnerable to lesions due to its protracted developmental course, are examined. In addition, timetables for development of executive skills, which emerge in childhood and have a prolonged developmental course that parallels development of the PFC, are also discussed. CONCLUSIONS: Equipped with this knowledge, researchers are now in a better position to understand functional recovery and outcome in children with brain conditions.
BACKGROUND: While many children with brain conditions present with cognitive, behavioural, emotional, academic and social impairments, other children recover with seemingly few impairments. Animal studies and preliminary child studies have identified timing of brain lesion as a key predictor in determining functional outcome following early brain lesions. REVIEW: This research suggests that knowledge of healthy developmental processes in brain structure and function is essential for better understanding functional recovery and outcome in children with brain lesions. This review paper aims to equip researchers with current knowledge of key principles of developmental processes in brain structure and function. Timetables for development of the prefrontal cortex (PFC), a brain region particularly vulnerable to lesions due to its protracted developmental course, are examined. In addition, timetables for development of executive skills, which emerge in childhood and have a prolonged developmental course that parallels development of the PFC, are also discussed. CONCLUSIONS: Equipped with this knowledge, researchers are now in a better position to understand functional recovery and outcome in children with brain conditions.
Authors: Craig D C Bailey; Nyresa C Alves; Raad Nashmi; Mariella De Biasi; Evelyn K Lambe Journal: Biol Psychiatry Date: 2011-10-25 Impact factor: 13.382
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Authors: Corina O Bondi; Bridgette D Semple; Linda J Noble-Haeusslein; Nicole D Osier; Shaun W Carlson; C Edward Dixon; Christopher C Giza; Anthony E Kline Journal: Neurosci Biobehav Rev Date: 2014-12-10 Impact factor: 8.989
Authors: Mardee Greenham; Megan M Spencer-Smith; Peter J Anderson; Lee Coleman; Vicki A Anderson Journal: Front Hum Neurosci Date: 2010-03-22 Impact factor: 3.169