Applications of metabolomics to understanding obesity in mouse and man.

The functional genomic approach of metabolomics consists of the application of a global analytical tool to profile metabolism in a cell, tissue or organism. The most popular analytical tools include high-resolution (1)H nuclear magnetic resonance spectroscopy and mass spectrometry. Metabolomics is high throughput and relatively cheap on a per-sample basis and, hence, ideal for collecting large data sets. Biofluids are being used to follow the progression of obesity both in animal models and humans, while tissue extracts can be examined to probe the mechanisms responsible for these biofluid changes. Given these benefits and the results already produced in the field, metabolomics will play an increasing role in understanding the progression of obesity.