Death of memory T-cell subsets in humans: changes during aging.

Aging is characterized by a progressive decline in various T-cell functions that are associated with a deficiency of naive and central memory T-cell subsets and the accumulation of oligoclonal effector memory T-cell subsets. In this article, we briefly review different pathways of death signaling and alterations in apoptotic signaling pathways in order to understand changes in various T cells in human aging.