Literature DB >> 20472433

New aminopropandiol derivatives as orally available and short-acting calcium-sensing receptor antagonists.

Yuko Shinagawa1, Teruhiko Inoue, Kazuyuki Hirata, Takeo Katsushima, Takashi Nakagawa, Yushi Matsuo, Masanori Shindo, Hiromasa Hashimoto.   

Abstract

Synthesis and structure-activity relationship studies on a new aminopropandiol class of derivatives as calcium-sensing receptor antagonists are described. Modification of the phenolic moiety of a calcilytic compound NPS 2143 led to the identification of an orally available compound (R,R)-31 which demonstrated a rapid and transient stimulation of PTH release in rats. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20472433     DOI： 10.1016/j.bmcl.2010.04.035

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  2 in total

1.  Discovery of a potent and short-acting oral calcilytic with a pulsatile secretion of parathyroid hormone.

Authors:  Yuko Shinagawa; Teruhiko Inoue; Takeo Katsushima; Toshihiro Kiguchi; Taku Ikenogami; Naoki Ogawa; Kenji Fukuda; Kazuyuki Hirata; Kazuhito Harada; Masaki Takagi; Takashi Nakagawa; Shuichi Kimura; Yushi Matsuo; Mariko Maekawa; Mikio Hayashi; Yuki Soejima; Mitsuru Takahashi; Masanori Shindo; Hiromasa Hashimoto
Journal:  ACS Med Chem Lett       Date:  2010-12-29       Impact factor: 4.345

2.  Mechanisms of Pancreatic Injury Induced by Basic Amino Acids Differ Between L-Arginine, L-Ornithine, and L-Histidine.

Authors:  Xiaoying Zhang; Tao Jin; Na Shi; Linbo Yao; Xinmin Yang; Chenxia Han; Li Wen; Dan Du; Peter Szatmary; Rajarshi Mukherjee; Tingting Liu; Qing Xia; David N Criddle; Wei Huang; Michael Chvanov; Robert Sutton
Journal:  Front Physiol       Date:  2019-01-15       Impact factor: 4.566
  2 in total

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