Tiziana Ciarambino1, Nicoletta Ferrara1, Pietro Castellino2, Giuseppe Paolisso1, Ludovico Coppola1, Mauro Giordano3. 1. Department of Gerontology, Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy. 2. Department of Internal Medicine, University of Catania, Catania, Italy. 3. Department of Gerontology, Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy. Electronic address: mauro.giordano@unina2.it.
Abstract
OBJECTIVES: Late-life depression is one of the main health problems among elderly diabetic subjects. In addition, depression is a common psychopathological condition among renal failure patients and most of these patients follow a low protein diet regimen (LPD). However, the effects of LPD on depressive symptoms are unclear. DESIGN: In the present study, the effects of LPD regimen on depressive symptoms in elderly type 2 diabetic subjects with renal failure were investigated. PARTICIPANTS: Fifty-two young-old type 2 diabetic patients with renal failure were enrolled in the study. All participants after normal protein diet regimen providing 1.2g/kg per d were instructed to consume either a LPD providing 0.8 g/kg per d, 7 d a wk (LPD 7/7), or a LPD providing 0.8 g/kg per d 6 d a wk (LPD 6/7) randomly. RESULTS:Mean 15-item Geriatric Depression Scale (GDS-15) (2.0±0.6) and Beck Depression Inventory (BDI) (4.1±1.0), during normal protein diet regimen, significantly increased to (6.7±1.6) and (12.2±1.4), respectively, after LPD 7/7 (P<0.05 versus normal protein diet). However, after LPD 6/7, mean GDS-15 and BDI significantly decreased to (4.4±1.5) and (6.7±1.6), respectively (P<0.05 versus LPD 7/7). CONCLUSION:LPD 6/7 regimen significantly decreased depressive symptoms in young-old type 2 diabetic patients.
RCT Entities:
OBJECTIVES: Late-life depression is one of the main health problems among elderly diabetic subjects. In addition, depression is a common psychopathological condition among renal failurepatients and most of these patients follow a low protein diet regimen (LPD). However, the effects of LPD on depressive symptoms are unclear. DESIGN: In the present study, the effects of LPD regimen on depressive symptoms in elderly type 2 diabetic subjects with renal failure were investigated. PARTICIPANTS: Fifty-two young-old type 2 diabeticpatients with renal failure were enrolled in the study. All participants after normal protein diet regimen providing 1.2g/kg per d were instructed to consume either a LPD providing 0.8 g/kg per d, 7 d a wk (LPD 7/7), or a LPD providing 0.8 g/kg per d 6 d a wk (LPD 6/7) randomly. RESULTS: Mean 15-item Geriatric Depression Scale (GDS-15) (2.0±0.6) and Beck Depression Inventory (BDI) (4.1±1.0), during normal protein diet regimen, significantly increased to (6.7±1.6) and (12.2±1.4), respectively, after LPD 7/7 (P<0.05 versus normal protein diet). However, after LPD 6/7, mean GDS-15 and BDI significantly decreased to (4.4±1.5) and (6.7±1.6), respectively (P<0.05 versus LPD 7/7). CONCLUSION:LPD 6/7 regimen significantly decreased depressive symptoms in young-old type 2 diabeticpatients.
Authors: Xiu Yang; Ming Yang; Ming Cheng; Li-Bin Ma; Xiang-Cheng Xie; Shuai Han; Bo Zhang; Xiao Fei; Ming Wang; Chang-Lin Mei Journal: Biomed Res Int Date: 2015-12-15 Impact factor: 3.411